撤回：缺乏Raf-1激酶抑制蛋白的小鼠表现出过度的低氧诱导性肺动脉高压，作者为I·莫克罗夫特、B·多伊尔、M·尼尔森、W·科尔奇、K·迈尔和MR·麦克林。《英国药理学期刊》，第163卷第5期：948 - 963页，2011年6月发表；DOI 10.1111/j.1476 - 5381.2011.01305.x
Retracted: Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension, by I Morecroft, B Doyle, M Nilsen, W Kolch, K Mair and MR MacLean. British Journal of Pharmacology, volume 163(5): 948-963, published in June 2011; DOI 10.1111/j.1476-5381.2011.01305.x.
出版信息
Br J Pharmacol. 2017 May;174(9):911. doi: 10.1111/bph.13796.
The above article, published by the British Journal of Pharmacology in June 2011 (http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01305.x/full), has been retracted by agreement between the authors, the Journal Editor in Chief and John Wiley & Sons Ltd. Formal internal investigations by the British Journal of Pharmacology have concluded that inappropriate manipulation of western blots depicted in Figures 1, 8 and 9 has occurred. The non-corresponding authors (M MacLean, B Doyle, K Mair, M Nilsen, W Kolch) wish to state that they had no knowledge that the figures in question had been manipulated. These issues are currently being investigated by the University of Glasgow. The retraction statement has also been approved by The University of Glasgow Research Integrity Council. Reference Morecroft I, Doyle B, Nilsen M, Kolch W, Mair K and MacLean MR (2011). Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension. Brit J Pharmacol 163: 948-963. doi: 10.1111/j.1476-5381.2011.01305.x.
上述文章由《英国药理学期刊》于2011年6月发表（http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01305.x/full），经作者、期刊主编与约翰·威利父子有限公司协商一致后予以撤回。《英国药理学期刊》的正式内部调查得出结论，图1、图8和图9中所呈现的蛋白质免疫印迹存在不当处理情况。非通讯作者（M·麦克林、B·多伊尔、K·迈尔、M·尼尔森、W·科尔奇）声明，他们并不知晓相关图片被处理过。格拉斯哥大学目前正在对这些问题展开调查。撤回声明也已得到格拉斯哥大学研究诚信委员会的批准。参考文献：莫克罗夫特I、多伊尔B、尼尔森M、科尔奇W、迈尔K和麦克林MR（2011年）。缺乏Raf-1激酶抑制蛋白的小鼠表现出过度的低氧诱导性肺动脉高压。《英国药理学期刊》163卷：948 - 963页。doi: 10.1111/j.1476-5381.2011.01305.x 。
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