Innovative Center for Flexible Devices, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, P. R. China.
Adv Mater. 2017 Jul;29(26). doi: 10.1002/adma.201605529. Epub 2017 Apr 11.
A large amount of evidence has demonstrated the revolutionary role of nanosystems in the screening and shielding of biological systems. The explosive development of interfacing bioentities with programmable nanomaterials has conveyed the intriguing concept of nano-bio interfaces. Here, recent advances in functional biointegrated devices through the precise programming of nano-bio interactions are outlined, especially with regard to the rational assembly of constituent nanomaterials on multiple dimension scales (e.g., nanoparticles, nanowires, layered nanomaterials, and 3D-architectured nanomaterials), in order to leverage their respective intrinsic merits for different functions. Emerging nanotechnological strategies at nano-bio interfaces are also highlighted, such as multimodal diagnosis or "theragnostics", synergistic and sequential therapeutics delivery, and stretchable and flexible nanoelectronic devices, and their implementation into a broad range of biointegrated devices (e.g., implantable, minimally invasive, and wearable devices). When utilized as functional modules of biointegrated devices, these programmable nano-bio interfaces will open up a new chapter for precision nanomedicine.
大量证据表明，纳米系统在生物系统的筛选和屏蔽方面发挥了革命性作用。可编程纳米材料与生物实体的接口的飞速发展，传达了纳米-生物界面的迷人概念。本文概述了通过精确编程纳米-生物相互作用来构建功能生物集成器件的最新进展，特别是涉及到在多个维度尺度上（例如，纳米粒子、纳米线、层状纳米材料和 3D 结构纳米材料）合理组装组成纳米材料，以利用它们各自的内在优势实现不同的功能。还强调了纳米-生物界面处新兴的纳米技术策略，例如多模式诊断或“治疗学”、协同和序贯治疗药物输送以及可拉伸和灵活的纳米电子器件，及其在广泛的生物集成器件（例如，可植入、微创和可穿戴设备）中的应用。当这些可编程纳米-生物界面被用作生物集成器件的功能模块时，将为精准纳米医学开辟一个新篇章。
