Akutko Katarzyna, Matusiewicz Krzysztof
2nd Department and Clinic of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland.
Adv Clin Exp Med. 2017 Jan-Feb;26(1):149-154. doi: 10.17219/acem/61428.
A number of reports on the pathogenic influence of Campylobacter concisus on the human body and its role in many diseases of the gastrointestinal system, including gastroesophageal reflux disease, Barrett's esophagus and inflammatory bowel disease, have appeared lately. Campylobacter concisus is a Gram negative bacteria which requires an anaerobic environment or microaerophilic environment with hydrogen for growth and is therefore difficult to culture. Due to this difficulty, the rate of infections in epidemiological data are underestimated. There are reports that C. concisus was the only pathogen isolated from the stool of patients with acute diarrhea, which could indicate that it is an etiologic factor of acute gastrointestinal infections in humans. Moreover, the results of some studies suggest that infection with C. concisus is a factor predisposing to the development of gastroesophageal reflux disease and Barrett's esophagus, conditions which may be present before the development of cancer. There are also studies which indicate C. concisus infection as a trigger of inflammatory bowel disease, since it has been demonstrated that C. concisus is present more frequently in patients with newly diagnosed Crohn's disease than in a control group.
最近出现了一些关于简明弯曲杆菌对人体的致病影响及其在许多胃肠系统疾病（包括胃食管反流病、巴雷特食管和炎症性肠病）中作用的报告。简明弯曲杆菌是一种革兰氏阴性菌，需要厌氧环境或含氢气的微需氧环境才能生长，因此难以培养。由于这一困难，流行病学数据中的感染率被低估。有报告称，简明弯曲杆菌是从急性腹泻患者粪便中分离出的唯一病原体，这可能表明它是人类急性胃肠道感染的病因。此外，一些研究结果表明，感染简明弯曲杆菌是易患胃食管反流病和巴雷特食管的一个因素，这些情况可能在癌症发生之前就已存在。也有研究表明，简明弯曲杆菌感染是炎症性肠病的触发因素，因为已证明新诊断的克罗恩病患者中简明弯曲杆菌的出现频率高于对照组。
