Jonker Femkje A M, Te Poel Elodie, Bates Imelda, Boele van Hensbroek Michael
Global Child Health Group, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.
Liverpool School of Tropical Medicine, University of Liverpool, Liverpool, United Kingdom.
Br J Haematol. 2017 Jun;177(6):878-883. doi: 10.1111/bjh.14593. Epub 2017 Apr 11.
Globally, anaemia, iron deficiency and infections are responsible for a majority of the morbidity and mortality that occurs among children. As iron is essential for erythropoiesis and the human immune system, as well as a crucial element for many pathogens, these three conditions often interact. This article considers the question - have the studies conducted so far unravelled the potential complex interaction between these factors sufficiently enough to be able to develop universally applicable guidelines about iron treatment in children? It is possible, however, that the area is too complex and diverse, with many sub-populations, and that not universal, but tailor-made guidelines are needed based on some agreed principles.
在全球范围内，贫血、缺铁和感染是导致儿童发病和死亡的主要原因。由于铁对于红细胞生成和人类免疫系统至关重要，同时也是许多病原体的关键元素，这三种情况常常相互作用。本文探讨了一个问题——迄今为止所进行的研究是否已经充分揭示了这些因素之间潜在的复杂相互作用，从而能够制定出普遍适用的儿童铁治疗指南？然而，该领域可能过于复杂多样，存在许多亚人群，因此可能需要的不是通用指南，而是基于一些商定原则的量身定制的指南。
