School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
Graduate Institute of Natural Products, College of Medicine, Chang Gung University ; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
J Nat Prod. 2017 Apr 28;80(4):783-789. doi: 10.1021/acs.jnatprod.7b00039. Epub 2017 Apr 11.
Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.
从传统中药血竭中分离得到四个 A 型黄烷-3-醇二氢查耳酮二聚体，即龙因 A-D（1-4）。通过光谱和光谱分析确定了 1-4 的结构。化合物 1 和 2 对 fMLP/CB 诱导的超氧阴离子和弹性蛋白酶表现出显著的抑制作用。还阐明了化合物 2 抑制作用的信号通路。这些纯化的 A 型黄烷-3-醇二氢查耳酮是开发抗炎药物的新潜在先导化合物。
