Fujimoto Kayo, Coghill Lyndon M, Weier Christopher A, Hwang Lu-Yu, Kim Ju Yeong, Schneider John A, Metzker Michael L, Brown Jeremy M
1 School of Public Health, University of Texas Health Science Center at Houston , Houston, Texas.
2 Department of Biological Sciences and Museum of Natural Science, Louisiana State University , Baton Rouge, Louisiana.
AIDS Res Hum Retroviruses. 2017 Sep;33(9):935-940. doi: 10.1089/AID.2016.0228. Epub 2017 Apr 18.
We explore the phylogenetic relationships among HIV sequences sampled from young adult black men who have sex with men (YAB-MSM), who are connected through peer referral/social ties and who attend common venues. Using 196 viral sequences sampled from the peripheral blood mononuclear cells of 10 individuals, our preliminary phylogenetic results indicate that these socially connected YAB-MSM are infected with distantly related viruses and provide no evidence for viral transmission between network members. Our results suggest that HIV-prevention strategies that target young adult MSM should extend beyond their network members and local community.
我们探究了从年轻成年男男性行为者（YAB-MSM）中采集的HIV序列之间的系统发育关系，这些年轻成年男男性行为者通过同伴推荐/社会关系相互联系且常去相同场所。我们从10个人的外周血单核细胞中采集了196个病毒序列，初步系统发育结果表明，这些通过社会关系联系起来的年轻成年男男性行为者感染的是远缘相关病毒，且没有证据表明网络成员之间存在病毒传播。我们的结果表明，针对年轻成年男男性行为者的HIV预防策略应超越其网络成员和当地社区的范围。
