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本文引用的文献

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A simple method for the identification of aminoglycoside-modifying enzymes.一种鉴定氨基糖苷类修饰酶的简单方法。
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Relation between aminoglycoside 2"-O-nucleotidyltransferase activity and aminoglycoside resistance.氨基糖苷2”-O-核苷酸基转移酶活性与氨基糖苷耐药性之间的关系
Antimicrob Agents Chemother. 1984 Feb;25(2):234-7. doi: 10.1128/AAC.25.2.234.
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Aminoglycoside phosphotransferase-II-mediated amikacin resistance in Escherichia coli.大肠杆菌中氨基糖苷磷酸转移酶-II介导的阿米卡星耐药性。
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New plasmid-mediated aminoglycoside adenylyltransferase of broad substrate range that adenylylates amikacin.新的质粒介导的具有广泛底物范围的氨基糖苷腺苷酸转移酶，该酶可使阿米卡星腺苷酸化。
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Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.携带R因子的大肠杆菌对氨基糖苷类抗生素的酶促乙酰化作用。
Biochemistry. 1971 May 11;10(10):1787-96. doi: 10.1021/bi00786a009.
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[Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase].[由一种同工酶，卡那霉素乙酰转移酶诱导产生的对氨基糖苷类抗生素的耐药性]
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Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin.肺炎克雷伯菌和阴沟肠杆菌中与妥布霉素酶促乙酰化相关的可转移的妥布霉素耐药性。
Antimicrob Agents Chemother. 1974 Oct;6(4):492-7. doi: 10.1128/AAC.6.4.492.
8
Correlation of aminoglycoside resistance with the KmS and Vmax/Km ratios of enzymatic modification of aminoglycosides by 2''-O-nucleotidyltransferase.氨基糖苷类耐药性与2''-O-核苷酸转移酶对氨基糖苷类进行酶促修饰的KmS及Vmax/Km比值的相关性。
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High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake.大肠杆菌中由于磷酸化和氨基糖苷摄取受损导致的高水平阿米卡星耐药性。
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Resistance of bacteria to the newer aminoglycoside antibiotics: an epidemiological and enzymatic study.细菌对新型氨基糖苷类抗生素的耐药性：一项流行病学与酶学研究。
J Antibiot (Tokyo). 1977 Aug;30(8):655-64. doi: 10.7164/antibiotics.30.655.

氨基糖苷浓度对氨基糖苷修饰酶反应速率的影响。

Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes.

作者信息

Bongaerts G P, Vliegenthart J S

机构信息

Department of Medical Microbiology, State University of Leiden, The Netherlands.

出版信息

Antimicrob Agents Chemother. 1988 May;32(5):740-6. doi: 10.1128/AAC.32.5.740.

DOI:10.1128/AAC.32.5.740
PMID:2840015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172263/
Abstract

Reaction rates of several reference aminoglycoside-modifying enzymes were studied at various substrate concentrations. The resulting concentration-response curves showed wide variation in threshold concentration, in curve slope, in enzyme saturation, and in substrate inhibition. Together, the curves of a defined aminoglycoside panel yielded more specific information for each individual aminoglycoside-modifying enzyme tested than did conventional substrate profiles obtained at a single substrate concentration.

摘要

在不同底物浓度下研究了几种参考氨基糖苷修饰酶的反应速率。所得的浓度-反应曲线在阈值浓度、曲线斜率、酶饱和度和底物抑制方面表现出广泛差异。总体而言，对于每种测试的氨基糖苷修饰酶，一组特定氨基糖苷的曲线比在单一底物浓度下获得的传统底物谱提供了更具体的信息。