癌症对宿主生理的操控：胰腺癌的启示
Cancer Manipulation of Host Physiology: Lessons from Pancreatic Cancer.
作者信息
Zambirinis Constantinos P, Miller George
机构信息
Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Surgery, Harlem Hospital, Columbia University Medical Center, New York, NY 10037, USA.
Department of Surgery, New York University School of Medicine, New York, NY 10016, USA; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Trends Mol Med. 2017 May;23(5):465-481. doi: 10.1016/j.molmed.2017.03.003. Epub 2017 Apr 8.
Homeostasis is a fundamental property of living organisms enabling the human body to withstand internal and external insults. In several chronic diseases, and especially in cancer, many homeostatic mechanisms are deranged. Pancreatic cancer in particular is notorious for its ability to invoke an intense fibroinflammatory stromal reaction facilitating its progression and resistance to treatment. In the past decade, several seminal discoveries have elucidated previously unrecognized modes of commandeering the host's defense systems. Here we review novel discoveries in pancreatic cancer immunobiology and attempt to integrate the notion of deranged homeostasis in the pathogenesis of this disease. We also highlight areas of controversy and obstacles that need to be overcome, hoping to further our mechanistic insight into this malignancy.
内环境稳态是生物体的一项基本特性，使人体能够抵御内部和外部的侵害。在多种慢性疾病中，尤其是癌症，许多内环境稳态机制都会失调。胰腺癌尤其因其引发强烈的纤维炎症性基质反应从而促进其进展和产生治疗抗性的能力而声名狼藉。在过去十年中，一些重大发现阐明了以前未被认识的操控宿主防御系统的模式。在此，我们回顾胰腺癌免疫生物学的新发现，并尝试将失调的内环境稳态概念整合到该疾病的发病机制中。我们还强调了存在争议的领域和需要克服的障碍，希望能进一步加深我们对这种恶性肿瘤的机制理解。
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