Yu Chen, Fan Xueli, Li Zhenlu, Liu Xiaoming, Wang Gang
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Department of Dermatology, Henan Provincial People's Hospital, Henan, China.
Eur J Dermatol. 2017 Apr 1;27(2):150-154. doi: 10.1684/ejd.2016.2946.
Although acitretin has been widely used for the treatment of psoriasis, additional safer and more effective approaches, including traditional Chinese medicine, are needed. To investigate the efficacy and safety of total glucosides of paeony (TGP) combined with acitretin in the treatment of moderate-to-severe plaque psoriasis. A randomised, double-blind, placebo-controlled, multi-centre clinical study was conducted. In total, 108 patients with moderate-to-severe plaque psoriasis were randomly assigned to treatment with "TGP plus acitretin" (group A) or "placebo plus acitretin" (group B) for 12 weeks. After 12 weeks of therapy, the percentage of patients achieving a 50% reduction in Psoriasis Area and Severity Index was 90% in group A and 70.5% in group B (p<0.05). The rate of serum alanine aminotransferase elevation was 6.25% in group A and 20.4% in group B (p<0.05). TGP is conducive to enhancing anti-psoriatic efficacy and reducing liver damage due to acitretin. TGP combined with acitretin is a safe and effective treatment approach for moderate-to-severe plaque psoriasis.
尽管阿维A已被广泛用于治疗银屑病，但仍需要包括中药在内的更安全、更有效的其他治疗方法。为了研究白芍总苷（TGP）联合阿维A治疗中度至重度斑块状银屑病的疗效和安全性。开展了一项随机、双盲、安慰剂对照、多中心临床研究。总共108例中度至重度斑块状银屑病患者被随机分配接受“TGP加阿维A”治疗（A组）或“安慰剂加阿维A”治疗（B组），为期12周。治疗12周后，银屑病面积和严重程度指数降低50%的患者百分比在A组为90%，在B组为70.5%（p<0.05）。A组血清丙氨酸氨基转移酶升高率为6.25%，B组为20.4%（p<0.05）。TGP有助于增强抗银屑病疗效并减少阿维A引起的肝损伤。TGP联合阿维A是治疗中度至重度斑块状银屑病的一种安全有效的治疗方法。
