Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.
Front Cell Infect Microbiol. 2024 Feb 15;14:1279220. doi: 10.3389/fcimb.2024.1279220. eCollection 2024.
Oral lichen planus (OLP), a T-lymphocyte-mediated disease of the oral mucosa, has a complex pathogenesis that involves a number of factors. The disease is characterized by recurrent episodes and requires continuous follow up, and there is no curative treatment available. Erosive lichen planus, among others, has a risk of malignant transformation and requires standardized treatment to control its progression. Different clinical subtypes of oral lichen planus require appropriate treatment. Pharmacological treatments are the most widely available and have the greatest variety of options and a number of novel pharmacological treatments are presented as highlights, including JAK enzyme inhibitors. The second is photodynamic therapy, which is the leading physiological treatment. In addition, periodontal treatment and psychological treatment should not be neglected. In this review, we briefly discuss the most recent developments in therapies for oral lichen planus after summarizing the most widely used clinical treatments, aiming to provide different proposals for future clinical treatment.
口腔扁平苔藓（OLP）是一种 T 淋巴细胞介导的口腔黏膜疾病，具有复杂的发病机制，涉及多种因素。该病具有反复发作的特点，需要持续随访，目前尚无根治方法。糜烂型扁平苔藓等有恶变风险，需要规范化治疗以控制其进展。口腔扁平苔藓的不同临床亚型需要进行相应的治疗。药物治疗是最广泛应用的治疗方法，具有最多的选择和一些新的药物治疗方法作为亮点，包括 JAK 酶抑制剂。其次是光动力疗法，是主要的生理性治疗方法。此外，牙周治疗和心理治疗也不容忽视。本文在总结最常用的临床治疗方法的基础上，简要讨论了口腔扁平苔藓治疗的最新进展，旨在为未来的临床治疗提供不同的建议。
