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本文引用的文献

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Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.自体诱导干细胞衍生的视网膜细胞治疗黄斑变性。
N Engl J Med. 2017 Mar 16;376(11):1038-1046. doi: 10.1056/NEJMoa1608368.
2
3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development.人多能干细胞在RGD-藻酸盐水凝胶中的3D培养可改善视网膜组织发育。
Acta Biomater. 2017 Feb;49:329-343. doi: 10.1016/j.actbio.2016.11.016. Epub 2016 Nov 5.
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Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism.通过化学定义的发育机制重现从多能干细胞生成具有靶标特异性的功能性人类视网膜神经节细胞。
Stem Cells. 2017 Mar;35(3):572-585. doi: 10.1002/stem.2513. Epub 2016 Oct 26.
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Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models.在MHC匹配模型中成功移植来自MHC纯合子诱导多能干细胞的视网膜色素上皮细胞。
Stem Cell Reports. 2016 Oct 11;7(4):635-648. doi: 10.1016/j.stemcr.2016.08.010. Epub 2016 Sep 15.
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Glaucoma: the retina and beyond.青光眼：视网膜及其他相关领域
Acta Neuropathol. 2016 Dec;132(6):807-826. doi: 10.1007/s00401-016-1609-2. Epub 2016 Aug 20.
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Enriched retinal ganglion cells derived from human embryonic stem cells.人胚胎干细胞来源的富集视网膜神经节细胞。
Sci Rep. 2016 Aug 10;6:30552. doi: 10.1038/srep30552.
7
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.用于治疗视网膜退行性失明的患者特异性诱导多能干细胞和光感受器前体细胞的cGMP生产。
Sci Rep. 2016 Jul 29;6:30742. doi: 10.1038/srep30742.
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Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice.人多能干细胞源性光感受器祖细胞在盲鼠中的功能。
Sci Rep. 2016 Jul 13;6:29784. doi: 10.1038/srep29784.
9
In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications.追求真实性：用于临床应用的诱导多能干细胞衍生视网膜色素上皮细胞
Stem Cells Transl Med. 2016 Nov;5(11):1562-1574. doi: 10.5966/sctm.2016-0037. Epub 2016 Jul 11.
10
Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy.干细胞衍生的光感受器移植以不同方式整合到视锥-视杆营养不良小鼠模型中。
Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3509-20. doi: 10.1167/iovs.16-19087.

用于视网膜疾病的干细胞疗法：重现发育过程以替代退化细胞。

Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells.

作者信息

Zhao Cuiping, Wang Qingjie, Temple Sally

机构信息

Neural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA.

Neural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA

出版信息

Development. 2017 Apr 15;144(8):1368-1381. doi: 10.1242/dev.133108.

DOI:10.1242/dev.133108
PMID:28400433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5399657/
Abstract

Retinal degenerative diseases are the leading causes of blindness worldwide. Replacing lost retinal cells via stem cell-based therapies is an exciting, rapidly advancing area of translational research that has already entered the clinic. Here, we review the status of these clinical efforts for several significant retinal diseases, describe the challenges involved and discuss how basic developmental studies have contributed to and are needed to advance clinical goals.

摘要

视网膜退行性疾病是全球失明的主要原因。通过基于干细胞的疗法替代丢失的视网膜细胞是一个令人兴奋且发展迅速的转化研究领域，该领域已进入临床阶段。在此，我们综述了针对几种重要视网膜疾病的这些临床研究进展，描述了其中涉及的挑战，并讨论了基础发育研究如何推动了临床目标以及为实现临床目标还需要哪些基础发育研究。