• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于磁性氧化铁纳米颗粒的生物相容性胶体悬浮液：合成、表征及毒理学概况

Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile.

作者信息

Coricovac Dorina-Elena, Moacă Elena-Alina, Pinzaru Iulia, Cîtu Cosmin, Soica Codruta, Mihali Ciprian-Valentin, Păcurariu Cornelia, Tutelyan Victor A, Tsatsakis Aristidis, Dehelean Cristina-Adriana

机构信息

Faculty of Pharmacy, "Victor Babecs" University of Medicine and Pharmacy Timişoara, Romania.

Faculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy Timişoara, Romania.

出版信息

Front Pharmacol. 2017 Mar 28;8:154. doi: 10.3389/fphar.2017.00154. eCollection 2017.

DOI:10.3389/fphar.2017.00154
PMID:28400730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5368253/
Abstract

The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles as future theranostic tools for skin pathology and (ii) to test their effects on human keratinocytes (HaCat cells) and by employing an animal model of acute dermal toxicity. Biocompatible colloidal suspensions were obtained by coating the magnetic iron oxide nanoparticles resulted during the solution combustion synthesis with a double layer of oleic acid, as innovative procedure in increasing bioavailability. The colloidal suspensions were characterized in terms of dynamic light scattering (DLS) and transmission electron microscopy (TEM). The effects of these suspensions were tested by means of Alamar blue assay and the noxious effects at skin level were measured using non-invasive methods. The results indicated a lack of toxicity on normal human cells induced by the iron oxide nanoparticles colloidal suspensions after an exposure of 24 h to different concentrations (5, 10, and 25 μg·mL). The dermal acute toxicity test showed that the topical applications of the colloidal suspensions on female and male SKH-1 hairless mice were not associated with significant changes in the quality of barrier skin function.

摘要

近年来，由于磁性氧化铁纳米颗粒在生物医学领域的多种应用，尤其是在癌症等领域，其在生物医学中的应用得到了迅猛发展。本研究的目的是：（i）开发基于磁性氧化铁纳米颗粒的生物相容性胶体悬浮液，作为未来皮肤病理学的治疗诊断工具；（ii）通过使用急性皮肤毒性动物模型，测试其对人角质形成细胞（HaCat细胞）的影响。通过用油酸双层包覆溶液燃烧合成过程中产生的磁性氧化铁纳米颗粒，获得了生物相容性胶体悬浮液，这是提高生物利用度的创新方法。通过动态光散射（DLS）和透射电子显微镜（TEM）对胶体悬浮液进行了表征。通过alamar蓝测定法测试了这些悬浮液的效果，并使用非侵入性方法测量了皮肤水平的有害影响。结果表明，在暴露于不同浓度（5、10和25μg·mL）24小时后，氧化铁纳米颗粒胶体悬浮液对正常人细胞没有毒性。皮肤急性毒性试验表明，在雌性和雄性SKH-1无毛小鼠上局部应用胶体悬浮液与屏障皮肤功能质量的显著变化无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/a1a6bf8a78d2/fphar-08-00154-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/9b7247b9c5fc/fphar-08-00154-g0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/dc9da59e02e0/fphar-08-00154-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/5d94c825848e/fphar-08-00154-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/98db66818da0/fphar-08-00154-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/a7a9672983a5/fphar-08-00154-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/f55cea6948ea/fphar-08-00154-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/bd604f24acc4/fphar-08-00154-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/ce9bfaeedc7b/fphar-08-00154-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/e804f93ee2ea/fphar-08-00154-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/161483031b24/fphar-08-00154-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/8b37e298bd45/fphar-08-00154-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/c531d7fa0a7f/fphar-08-00154-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/9ee74c56bf8d/fphar-08-00154-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/a1a6bf8a78d2/fphar-08-00154-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/9b7247b9c5fc/fphar-08-00154-g0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/dc9da59e02e0/fphar-08-00154-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/5d94c825848e/fphar-08-00154-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/98db66818da0/fphar-08-00154-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/a7a9672983a5/fphar-08-00154-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/f55cea6948ea/fphar-08-00154-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/bd604f24acc4/fphar-08-00154-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/ce9bfaeedc7b/fphar-08-00154-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/e804f93ee2ea/fphar-08-00154-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/161483031b24/fphar-08-00154-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/8b37e298bd45/fphar-08-00154-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/c531d7fa0a7f/fphar-08-00154-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/9ee74c56bf8d/fphar-08-00154-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95d/5368253/a1a6bf8a78d2/fphar-08-00154-g0013.jpg

相似文献

1
Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile.基于磁性氧化铁纳米颗粒的生物相容性胶体悬浮液：合成、表征及毒理学概况
Front Pharmacol. 2017 Mar 28;8:154. doi: 10.3389/fphar.2017.00154. eCollection 2017.
2
Oleic Acid Double Coated Fe₃O₄ Nanoparticles as Anti-Melanoma Compounds with a Complex Mechanism of Activity- and Assessment.油酸双包覆Fe₃O₄纳米颗粒作为具有复杂活性机制的抗黑色素瘤化合物及评估
J Biomed Nanotechnol. 2019 May 1;15(5):893-909. doi: 10.1166/jbn.2019.2726.
3
Characterization of fullerene colloidal suspension in a cell culture medium for in vitro toxicity assessment.用于体外毒性评估的细胞培养基中富勒烯胶体悬浮液的表征
Mol Biosyst. 2010 Jul;6(7):1238-46. doi: 10.1039/c002364g. Epub 2010 Apr 22.
4
Enhanced bio-compatibility of ferrofluids of self-assembled superparamagnetic iron oxide-silica core-shell nanoparticles.自组装超顺磁性氧化铁-二氧化硅核壳纳米颗粒的铁磁流体的生物相容性增强。
J Nanosci Nanotechnol. 2011 Mar;11(3):1958-67. doi: 10.1166/jnn.2011.3578.
5
The effect of magnetically induced linear aggregates on proton transverse relaxation rates of aqueous suspensions of polymer coated magnetic nanoparticles.磁场诱导线性聚集体对聚合物包覆磁性纳米粒子水悬浮液中质子横向弛豫率的影响。
Nanoscale. 2013 Mar 7;5(5):2152-63. doi: 10.1039/c3nr32979h. Epub 2013 Feb 6.
6
Comparative analysis of the 1H NMR relaxation enhancement produced by iron oxide and core-shell iron-iron oxide nanoparticles.氧化铁和核壳型铁-氧化铁纳米颗粒产生的1H NMR弛豫增强的比较分析。
Magn Reson Imaging. 2007 Dec;25(10):1437-41. doi: 10.1016/j.mri.2007.04.006. Epub 2007 Jun 13.
7
Biocompatible Magnetic Colloidal Suspension Used as a Tool for Localized Hyperthermia in Human Breast Adenocarcinoma Cells: Physicochemical Analysis and Complex In Vitro Biological Profile.生物相容性磁性胶体悬浮液用作人乳腺腺癌细胞局部热疗的工具：物理化学分析和复杂的体外生物学特征
Nanomaterials (Basel). 2021 Apr 30;11(5):1189. doi: 10.3390/nano11051189.
8
Auto-degradable and biocompatible superparamagnetic iron oxide nanoparticles/polypeptides colloidal polyion complexes with high density of magnetic material.具有高磁材料密度的自降解和生物相容的超顺磁性氧化铁纳米粒子/多肽胶体聚离子复合物。
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109920. doi: 10.1016/j.msec.2019.109920. Epub 2019 Jun 27.
9
Structural characterization of polysaccharide-coated iron oxide nanoparticles produced by Staphylococcus warneri, isolated from a thermal spring.由温泉中分离的沃氏葡萄球菌产生的多糖包覆氧化铁纳米粒子的结构特征。
J Basic Microbiol. 2019 Jun;59(6):569-578. doi: 10.1002/jobm.201800684. Epub 2019 Apr 30.
10
Multifunctional theranostic applications of biocompatible green-synthesized colloidal nanoparticles.生物相容的绿色合成胶体纳米粒子的多功能治疗应用。
Appl Microbiol Biotechnol. 2018 May;102(10):4393-4408. doi: 10.1007/s00253-018-8928-2. Epub 2018 Mar 29.

引用本文的文献

1
Computational Design of Mineral-Based Materials: Iron Oxide Nanoparticle-Functionalized Polymeric Films for Enhanced Public Water Purification.矿物基材料的计算设计：用于强化公共水净化的氧化铁纳米颗粒功能化聚合物薄膜
Polymers (Basel). 2025 Jul 31;17(15):2106. doi: 10.3390/polym17152106.
2
FeO@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment.FeO@β-环糊精纳米系统：癌症治疗中一种有前景的辅助方法。
Nanomaterials (Basel). 2025 Aug 4;15(15):1192. doi: 10.3390/nano15151192.
3
Applications and Efficacy of Iron Oxide Nanoparticles in the Treatment of Brain Tumors.

本文引用的文献

1
Effect of surfactant in mitigating cadmium oxide nanoparticle toxicity: Implications for mitigating cadmium toxicity in environment.表面活性剂缓解氧化镉纳米颗粒毒性的效果：对缓解环境中镉毒性的意义。
Environ Res. 2017 Jan;152:141-149. doi: 10.1016/j.envres.2016.10.005. Epub 2016 Oct 20.
2
Cardiotoxicity of nano-particles.纳米颗粒的心脏毒性。
Life Sci. 2016 Nov 15;165:91-99. doi: 10.1016/j.lfs.2016.09.017. Epub 2016 Sep 26.
3
The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells.
氧化铁纳米颗粒在脑肿瘤治疗中的应用及疗效
Pharmaceutics. 2025 Apr 9;17(4):499. doi: 10.3390/pharmaceutics17040499.
4
Analysis of the Antioxidant and Antimicrobial Activity, Cytotoxic, and Anti-Migratory Properties of the Essential Oils Obtained from Cultivated Medicinal Species.对从栽培药用植物中提取的精油的抗氧化、抗菌活性、细胞毒性和抗迁移特性的分析。
Plants (Basel). 2025 Mar 8;14(6):846. doi: 10.3390/plants14060846.
5
Comprehensive Biosafety Profile of Carbomer-Based Hydrogel Formulations Incorporating Phosphorus Derivatives.含磷衍生物的卡波姆基水凝胶制剂的综合生物安全性概况
Gels. 2024 Jul 18;10(7):477. doi: 10.3390/gels10070477.
6
Advances in the Optimization of Fe Nanoparticles: Unlocking Antifungal Properties for Biomedical Applications.铁纳米颗粒优化进展：解锁其在生物医学应用中的抗真菌特性
Pharmaceutics. 2024 May 10;16(5):645. doi: 10.3390/pharmaceutics16050645.
7
Toxic Kidney Damage in Rats Following Subchronic Intraperitoneal Exposure to Element Oxide Nanoparticles.大鼠亚慢性腹腔注射暴露于元素氧化物纳米颗粒后的肾毒性损伤
Toxics. 2023 Sep 19;11(9):791. doi: 10.3390/toxics11090791.
8
Combustion Synthesis of Magnetic Nanomaterials for Biomedical Applications.用于生物医学应用的磁性纳米材料的燃烧合成
Nanomaterials (Basel). 2023 Jun 21;13(13):1902. doi: 10.3390/nano13131902.
9
Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review.益生菌携带氧化铁纳米颗粒促进铁吸收：系统评价。
J Nanobiotechnology. 2023 Apr 10;21(1):124. doi: 10.1186/s12951-023-01880-9.
10
Chemical and Antimicrobial Characterization of L. and L. Essential Oils and In Vitro Potential Cytotoxic Effect in Human Colorectal Carcinoma Cells.L. 和 L. 精油的化学成分和抗菌特性及其对人结直肠癌细胞的体外潜在细胞毒性作用。
Molecules. 2022 Sep 19;27(18):6106. doi: 10.3390/molecules27186106.
物种和细胞类型对神经细胞中氧化铁纳米颗粒纳米安全性的影响。
J Nanobiotechnology. 2016 Sep 9;14(1):69. doi: 10.1186/s12951-016-0220-y.
4
Magnetic Resonance Imaging of Human-Derived Amniotic Membrane Stem Cells Using PEGylated Superparamagnetic Iron Oxide Nanoparticles.使用聚乙二醇化超顺磁性氧化铁纳米颗粒对人源羊膜干细胞进行磁共振成像
Cell J. 2016 Fall;18(3):332-9. doi: 10.22074/cellj.2016.4560. Epub 2016 Aug 24.
5
Improved biocompatibility and efficient labeling of neural stem cells with poly(L-lysine)-coated maghemite nanoparticles.聚（L-赖氨酸）包被的磁赤铁矿纳米颗粒改善了神经干细胞的生物相容性并实现了高效标记。
Beilstein J Nanotechnol. 2016 Jun 27;7:926-936. doi: 10.3762/bjnano.7.84. eCollection 2016.
6
Nanocarriers as Tools in Delivering Active Compounds for Immune System Related Pathologies.纳米载体作为递送活性化合物治疗免疫系统相关疾病的工具。
Recent Pat Nanotechnol. 2016;10(2):128-45. doi: 10.2174/1872210510999160427113345.
7
Protein bio-corona: critical issue in immune nanotoxicology.蛋白质生物冠层：免疫纳米毒理学中的关键问题。
Arch Toxicol. 2017 Mar;91(3):1031-1048. doi: 10.1007/s00204-016-1797-5. Epub 2016 Jul 20.
8
Sex differences and pathology status correlated to the toxicity of some common carcinogens in experimental skin carcinoma.性别差异和病理状态与实验性皮肤癌中某些常见致癌物的毒性相关。
Food Chem Toxicol. 2016 Sep;95:149-58. doi: 10.1016/j.fct.2016.07.007. Epub 2016 Jul 11.
9
Advanced Nanobiomaterials: Vaccines, Diagnosis and Treatment of Infectious Diseases.先进的纳米生物材料：传染病的疫苗、诊断与治疗
Molecules. 2016 Jul 1;21(7):867. doi: 10.3390/molecules21070867.
10
Are iron oxide nanoparticles safe? Current knowledge and future perspectives.氧化铁纳米颗粒安全吗？当前认知与未来展望。
J Trace Elem Med Biol. 2016 Dec;38:53-63. doi: 10.1016/j.jtemb.2016.03.017. Epub 2016 Mar 31.