Yang Yong-Dong, Yu Xing, Wang Xiu-Mei, Mu Xiao-Hong, He Feng
Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China; School of Materials Science and Engineering, Tsinghua University, Beijing, China.
Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Neural Regen Res. 2017 Feb;12(2):267-275. doi: 10.4103/1673-5374.200810.
Tanshinone IIA, extracted from Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone IIA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion (L-S) cells was less after treatment with tanshinone IIA. The effects of tanshinone IIA were similar to intravenous injection of 30 mg/kg methylprednisolone. These findings suggested that tanshinone IIA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control.
从丹参中提取的丹参酮IIA通过其抗炎、抗氧化和抗凋亡特性发挥神经保护作用。本研究将20mg/kg丹参酮IIA连续7天静脉注射到脊髓损伤大鼠模型中。结果表明，丹参酮IIA可减轻膀胱组织的炎症、水肿以及代偿性增厚，改善尿动力学参数，减轻继发性损伤，并促进脊髓再生。用丹参酮IIA治疗后，肥大和凋亡的背根神经节（L-S）细胞数量减少。丹参酮IIA的作用与静脉注射30mg/kg甲泼尼龙相似。这些发现表明，丹参酮IIA通过重塑参与下尿路控制的脊髓通路，改善脊髓损伤所致下尿路功能障碍后的功能恢复。
