School of Traumatology and Orthopedics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China.
Neural Regen Res. 2012 Dec 25;7(36):2882-8. doi: 10.3969/j.issn.1673-5374.2012.36.005.
Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection.
丹参酮 IIa 是丹参这种活血化瘀的传统中药的有效单体成分。丹参酮 IIa 可有效改善脑组织缺血/缺氧损伤。本研究建立了大鼠脊髓缺血再灌注损伤模型，并在模型建立前 0.5 小时经腹腔注射丹参酮 IIa。结果表明，丹参酮 IIa 可促进热休克蛋白 70 和 Bcl-2 蛋白表达，但抑制缺血再灌注损伤后损伤脊髓中 Bax 蛋白表达。此外，与阳性对照丹参注射液相比，Nissl 染色显示存在丹参酮 IIa 时神经细胞凋亡减少，病理损伤较少。
