UXT-AS1诱导的UXT可变剪接与结直肠癌的肿瘤进展相关。
UXT-AS1-induced alternative splicing of UXT is associated with tumor progression in colorectal cancer.
作者信息
Yin Jun, Luo Wei, Zeng Xiang, Zeng Lisi, Li Zhiyang, Deng Xiaofang, Tan Xiaojun, Hu Weimin
机构信息
Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University Guangzhou, Guangdong, China.
Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University Guangzhou, Guangdong, China.
出版信息
Am J Cancer Res. 2017 Mar 1;7(3):462-472. eCollection 2017.
Increasing evidence indicates that long non-coding RNAs (lncRNAs) can act as crucial regulators of tumor progression. In the present study, UXT-AS1 was found to be significantly upregulated in colorectal cancer (CRC) and high expression levels of UXT-AS1 were significantly associated with poor prognosis in CRC patients. In addition, upregulation of UXT-AS1 resulted in inhibition of cell apoptosis and the promotion of cell proliferation. Moreover, by regulating the alternative splicing of UXT, upregulation of UXT-AS1 decreased the UXT1 transcript which promoted cell apoptosis and increased the UXT2 transcript which promoted cell proliferation. Thus, aberrant high expression of UXT-AS1 can promote CRC progression by changing the alternative splicing of UXT from the UXT1 transcript to the UXT2 transcript. In conclusion, our findings suggest that the regulation of CRC progression is by UXT-AS1-induced alternative splicing of UXT, and the expression level of UXT-AS1 may be a potential prognostic biomarker and therapy target in CRC patients.
越来越多的证据表明，长链非编码RNA（lncRNA）可作为肿瘤进展的关键调节因子。在本研究中，发现UXT-AS1在结直肠癌（CRC）中显著上调，且UXT-AS1的高表达水平与CRC患者的不良预后显著相关。此外，UXT-AS1的上调导致细胞凋亡受到抑制且细胞增殖得到促进。而且，通过调节UXT的可变剪接，UXT-AS1的上调减少了促进细胞凋亡的UXT1转录本，并增加了促进细胞增殖的UXT2转录本。因此，UXT-AS1的异常高表达可通过将UXT的可变剪接从UXT1转录本转变为UXT2转录本来促进CRC进展。总之，我们的研究结果表明，CRC进展的调控是由UXT-AS1诱导的UXT可变剪接所致，且UXT-AS1的表达水平可能是CRC患者潜在的预后生物标志物和治疗靶点。
Zotero 插件