Ma Chenhui, Shi Xuefei, Zhu Qingqing, Li Qian, Liu Yafang, Yao Yanwen, Song Yong
Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China.
Department of Respiratory Medicine, Huzhou Central Hospital, Huzhou, China.
Tumour Biol. 2016 Feb;37(2):1437-44. doi: 10.1007/s13277-015-4521-9. Epub 2015 Dec 3.
Long noncoding RNAs (lncRNAs), which refer to a group of RNAs with length more than 200 nucleotides and limited protein-coding potential, play a widespread role in regulating biological processes, such as cell differentiation, proliferation, apoptosis, and migration. LncRNAs are dysregulated in multiple cancers, playing an either oncogenic or tumor-suppressive role. LncRNA GAS5 is a recently identified tumor suppressor involved in several cancers, like breast cancer, prostate cancer, lung cancer, and colorectal cancer. The low-expression pattern confers tumor cells elevated capacity of proliferation and predicts poorer prognosis. Existing studies mirror that lncRNA GAS5 promises to be a novel diagnostic biomarker, therapy target, as well as prognostic biomarker. In this review, we will summarize the current knowledge about this vital lncRNA, from its discovery, characteristics, and biological function to molecular mechanism in various neoplasms.
长链非编码RNA（lncRNAs）是指一组长度超过200个核苷酸且蛋白质编码潜力有限的RNA，在调节细胞分化、增殖、凋亡和迁移等生物学过程中发挥着广泛作用。lncRNAs在多种癌症中表达失调，发挥致癌或抑癌作用。lncRNA GAS5是最近发现的一种抑癌因子，参与乳腺癌、前列腺癌、肺癌和结直肠癌等多种癌症。低表达模式赋予肿瘤细胞更高的增殖能力，并预示着更差的预后。现有研究表明，lncRNA GAS5有望成为一种新型的诊断生物标志物、治疗靶点以及预后生物标志物。在这篇综述中，我们将总结关于这种重要lncRNA的当前知识，从其发现、特征、生物学功能到在各种肿瘤中的分子机制。
