Shahvazian Najmeh, Rafiee Mansour, Rahmanian Masoud, Razavi-Ratki Seyed Kazem, Farahzadi Mohammad Hadi
Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Department of Endocrinology and Metabolism, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Adv Biomed Res. 2017 Mar 7;6:28. doi: 10.4103/2277-9175.201685. eCollection 2017.
Remote ischemic preconditioning (RIPC) is a phenomenon where a short period of ischemia in one organ protects against further ischemia in the other organs. We hypothesized that RIPC occurring in diabetic patients with ankle brachial index (ABI) between 0.70 and 0.90 were included with peripheral arterial disease, would make the better coronary flow resulted in the increasing ABI.
This randomized clinical trial study was done in the Afshar Cardiovascular Hospital in Yazd between 2013 and 2014. Sixty participants were randomly divided into two groups (intervention and control groups). The intervention group was undergoing RIPC, and the control group was tested without RIPC. RIPC was stimulated by giving three cycles of 5 min of ischemia followed by 5 min of reperfusion of both upper arms using a blood pressure cuff inflated to 200 mm Hg ( = 30). This was compared with no RIPC group which consisted of placing a deflated blood pressure cuff on the upper limbs ( = 30).
The mean of ABI level before intervention in the RIPC and control group group was 0.82 ± 0.055 and 0.83 ± 0.0603 ( = 0.347) respectively, with no significant difference. It was 0.86 ± 0.066 in the RIPC group compared the control 0.83 ± 0.0603 ( = 0.046). So levels of ABI were greater after intervention in the RIPC group. The mean of ABI level increase from 0.82 ± 0.05 to 0.86 ± 0.06 in RIPC group ( = 0.008). So the intervention group showed a significant increase in ABI.
RIPC through using a simple, noninvasive technique, composing three cycles of 5 min-ischemia of both upper arms, showing a significant increase in ABI level in diabetic patients.
远程缺血预处理（RIPC）是一种现象，即一个器官的短时间缺血可保护其他器官免受进一步缺血的影响。我们假设，在患有外周动脉疾病且踝臂指数（ABI）在0.70至0.90之间的糖尿病患者中发生的RIPC，会使冠状动脉血流改善，从而导致ABI增加。
这项随机临床试验研究于2013年至2014年在亚兹德的阿夫沙尔心血管医院进行。60名参与者被随机分为两组（干预组和对照组）。干预组接受RIPC，对照组不进行RIPC测试。使用充气至200 mmHg的血压袖带对双臂进行三个周期的5分钟缺血，随后5分钟再灌注，以此刺激RIPC（n = 30）。将其与不进行RIPC的组进行比较，该组是在上肢放置一个放气的血压袖带（n = 30）。
RIPC组和对照组干预前ABI水平的平均值分别为0.82±0.055和0.83±0.0603（P = 0.347），无显著差异。RIPC组为0.86±0.066，对照组为0.83±0.0603（P = 0.046）。因此，RIPC组干预后的ABI水平更高。RIPC组的ABI水平平均值从0.82±0.05增加到0.86±0.06（P = 0.008）。所以干预组的ABI有显著增加。
通过使用一种简单的非侵入性技术进行RIPC，即对双臂进行三个周期的5分钟缺血，显示糖尿病患者的ABI水平显著增加。
