用于心血管保护的慢性远隔缺血预处理
Chronic remote ischemic conditioning for cardiovascular protection.
作者信息
Chong Jun, Bulluck Heerajnarain, Fw Ho Andrew, Boisvert William A, Hausenloy Derek J
机构信息
Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.
National Heart Centre Singapore, Singapore.
出版信息
Cond Med. 2019 Aug;2(4):164-169.
Abstract
New treatments are needed to prevent adverse left ventricular remodelling following acute myocardial infarction (AMI), in order to prevent heart failure and improve clinical outcomes following AMI. Remote ischemic conditioning (RIC) using transient limb ischemia and reperfusion has been reported to reduce myocardial infarct (MI) size in AMI patients treated by primary percutaneous coronary intervention, and whether it can improve clinical outcomes is currently being investigated. Interestingly, repeated daily episode of limb RIC (termed 'chronic remote ischemic conditioning', or CRIC) has been shown in experimental and clinical studies to confer beneficial effects on post-AMI cardiac remodelling and chronic heart failure. In addition, the beneficial effects of CRIC extend to vascular function, peripheral arterial disease and stroke. In this review article, we focus on the therapeutic potential of CRIC as a strategy for cardiovascular protection and for improving clinical outcomes in patients with cardiovascular disease.
摘要
为预防急性心肌梗死后不良的左心室重构，进而预防心力衰竭并改善急性心肌梗死后的临床结局，需要新的治疗方法。据报道，采用短暂肢体缺血和再灌注的远程缺血预处理（RIC）可减小接受直接经皮冠状动脉介入治疗的急性心肌梗死患者的心肌梗死面积，目前正在研究其是否能改善临床结局。有趣的是，实验和临床研究表明，每日重复进行肢体RIC（称为“慢性远程缺血预处理”，即CRIC）对急性心肌梗死后的心脏重构和慢性心力衰竭具有有益作用。此外，CRIC的有益作用还扩展到血管功能、外周动脉疾病和中风。在这篇综述文章中，我们重点关注CRIC作为一种心血管保护策略以及改善心血管疾病患者临床结局的治疗潜力。
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2
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