Diabetes Research Center, Medical School of Ningbo University, Ningbo, 315000 Zhejiang, China.
The Affiliated Hospital of Medical School of Ningbo University, Ningbo, 315000 Zhejiang, China.
J Diabetes Res. 2020 Jun 19;2020:3960857. doi: 10.1155/2020/3960857. eCollection 2020.
The correlation between diabetes and systematic well-being on human life has long established. As a common complication of diabetes, the prevalence of diabetic nephropathy (DN) has been increasing globally. DN is known to be a major cause of end-stage kidney disease (ESKD). Till now, the molecular mechanisms for DN have not been fully explored and the effective therapies are still lacking. Noncoding RNAs are a class of RNAs produced by genome transcription that cannot be translated into proteins. It has been documented that ncRNAs participate in the pathogenesis of DN by regulating inflammation, apoptosis, autophagy, cell proliferation, and other pathological processes. In this review, the pathological roles and diagnostic and therapeutic potential of three types of ncRNAs (microRNA, long noncoding RNA, and circular RNA) in the progression of DN are summarized and illustrated.
糖尿病与人类系统健康之间的相关性早已确立。作为糖尿病的常见并发症，糖尿病肾病（DN）的患病率在全球范围内不断上升。DN 是导致终末期肾病（ESKD）的主要原因。到目前为止，DN 的分子机制尚未被充分探索，有效的治疗方法仍然缺乏。非编码 RNA 是一类由基因组转录产生的不能翻译成蛋白质的 RNA。有文献记载，ncRNA 通过调节炎症、细胞凋亡、自噬、细胞增殖等病理过程参与 DN 的发病机制。本综述总结并说明了三种 ncRNA（microRNA、长链非编码 RNA 和环状 RNA）在 DN 进展中的病理作用及诊断和治疗潜力。
