Gillberg Christopher, Fernell Elisabeth, Kočovská Eva, Minnis Helen, Bourgeron Thomas, Thompson Lucy, Allely Clare S
Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Barts and London School of Medicine, Queen Mary University of London, Blizard Institute, 58 Turner Street, E1 2AB, London.
Autism Res. 2017 Jun;10(6):1022-1044. doi: 10.1002/aur.1777. Epub 2017 Apr 12.
Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the "autisms" [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as "steroid metabolism" and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. Autism Res 2017. © 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. Autism Res 2017, 10: 1022-1044. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.
基于相关研究文献的证据，我们提出一个假说：胆固醇、维生素D和类固醇激素之间可能存在联系，进而至少对部分“自闭症”的发展产生影响[科尔曼和吉尔伯格]。我们的假说由同行评审文献推动，假定胆固醇代谢（我们将其称为“类固醇代谢”）与自闭症谱系障碍（ASD）中各类类固醇异常（皮质醇、睾酮、雌激素、孕酮、维生素D）的发现之间可能存在联系。有必要开展进一步研究来调查这些潜在联系，以加深我们对ASD潜在生物学机制的理解。《自闭症研究》2017年。© 2017作者。《自闭症研究》由威利期刊公司代表国际自闭症研究协会出版。《自闭症研究》2017年，10: 1022 - 1044。© 2017国际自闭症研究协会，威利期刊公司。
