Interaction of cadmium ions with calcium hydroxyapatite crystals: a possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases.

Cadmium ions adsorb onto calcium hydroxyapatite crystals (HA) and are as effective as inorganic pyrophosphate and aluminum ions in retarding the rate of in vitro dissolution of HA. In contrast, cadmium ions have no important retarding effect on the growth of HA, but are built into the crystals, thus making them very resistant to subsequent dissolution. These effects could interfere with bone remodeling, with cadmium protecting normal sites of resorption and thus causing resorption at pathological sites.