Friberg L
Environ Health Perspect. 1984 Mar;54:1-11. doi: 10.1289/ehp.84541.
The paper is a review of certain aspects of importance of cadmium and the kidney regarding the assessment of risks and understanding of mechanisms of action. The review discusses the following topics: history and etiology of cadmium-induced kidney dysfunction and related disorders; cadmium metabolism, metallothionein and kidney dysfunction; cadmium in urine as indicator of body burden, exposure and kidney dysfunction; cadmium levels in kidney and liver as indicators of kidney dysfunction; characteristics of early kidney dysfunction; the critical concentration concept; critical concentrations of cadmium in kidney cortex; and prognosis.
本文是一篇关于镉与肾脏在风险评估及作用机制理解方面某些重要方面的综述。该综述讨论了以下主题：镉诱导的肾功能障碍及相关疾病的历史与病因；镉代谢、金属硫蛋白与肾功能障碍；尿镉作为身体负担、暴露及肾功能障碍指标；肾脏和肝脏中的镉水平作为肾功能障碍指标；早期肾功能障碍的特征；临界浓度概念；肾皮质中镉的临界浓度；以及预后。
