钴催化乙烯基芳烃的马氏选择性硼氢化反应。
Cobalt-catalysed Markovnikov selective hydroboration of vinylarenes.
作者信息
Peng Jingying, Docherty Jamie H, Dominey Andrew P, Thomas Stephen P
机构信息
EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.
GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, Hertfordshire, UK.
出版信息
Chem Commun (Camb). 2017 Apr 25;53(34):4726-4729. doi: 10.1039/c7cc01085k.
PMID:28401978
Abstract
A bipyridiyl-oxazoline cobalt catalyst BPOCoCl has been developed for the Markovnikov selective hydroboration of alkenes using pinacolborane and NaOBu as the in situ activator with up to >98 : 2 branched : linear selectivity (24 examples, 45-92% isolated yield).
摘要
已开发出一种联吡啶基-恶唑啉钴催化剂BPOCoCl，用于以频哪醇硼烷和叔丁醇钠作为原位活化剂，对烯烃进行马氏选择性硼氢化反应，支链与直链选择性高达>98:2（24个实例，分离产率45 - 92%）。
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