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PLCE 1与PRKCA的相关性在食管炎和食管癌中的临床意义

Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma.

作者信息

Guo Yongchen, Bao Yonghua, Ma Ming, Zhang Shanshan, Zhang Yongmeng, Yuan Ming, Liu Bing, Yang Yiqiong, Cui Wen, Ansong Emmanuel, Dong Huali, Macias Virgilia, Yang Wancai

机构信息

Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining 272067, China.

Department of Thoracic Surgery, Affiliated Hospital, Jining Medical University, Jining 272067, China.

出版信息

Oncotarget. 2017 May 16;8(20):33285-33299. doi: 10.18632/oncotarget.16635.

DOI:10.18632/oncotarget.16635
PMID:28402280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5464868/
Abstract

Esophagitis and Barrett's esophagus are linked to esophageal squamous cell carcinoma and adenocarcinoma, respectively. However, the underlying mechanisms are still unclear. This study analyzed the expression levels of and correlation between PLCE1 and PRKCA in human esophagitis, carcinogen NMBA-induced rat esophagus, PLCE1 genetic deficient mouse esophageal epithelial tissues and human esophageal cancer cell line, integrated with Online oncology data sets. We found that the expression levels of both PLCE1 and PRKCA were significantly elevated in human esophagitis, esophageal squamous cell carcinoma, Barrett's esophagus, esophageal adenocarcinoma and in NMBA-treated rat esophageal epithelia. However, PRKCA and cytokines were significantly downregulated in PLCE1-deficient mouse esophageal epithelia, and knockdown of PLCE1 in human esophageal cancer cells led to reduction of PRKCA and cytokines. Finally, high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers. In conclusion, this study defined the initiation and progression of esophageal inflammation and malignant transformation, in which the positive correlation of PLCE1 and PRKCA exhibits critical clinical significance.

摘要

食管炎和巴雷特食管分别与食管鳞状细胞癌和腺癌相关。然而，其潜在机制仍不清楚。本研究结合在线肿瘤数据集，分析了人食管炎、致癌物NMBA诱导的大鼠食管、PLCE1基因缺陷小鼠食管上皮组织及人食管癌细胞系中PLCE1和PRKCA的表达水平及其相关性。我们发现，PLCE1和PRKCA的表达水平在人食管炎、食管鳞状细胞癌、巴雷特食管、食管腺癌以及NMBA处理的大鼠食管上皮中均显著升高。然而，在PLCE1缺陷的小鼠食管上皮中，PRKCA和细胞因子显著下调，并且在人食管癌细胞中敲低PLCE1会导致PRKCA和细胞因子减少。最后，PLCE1和PRKCA的高表达均与食管癌患者的不良预后显著相关。总之，本研究明确了食管炎症和恶性转化的起始与进展过程，其中PLCE1和PRKCA的正相关具有关键的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/213d9cae7be8/oncotarget-08-33285-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/bb38ef08f4fb/oncotarget-08-33285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/b4522f5eaf46/oncotarget-08-33285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/77076a2abc0f/oncotarget-08-33285-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/92d88aa8a417/oncotarget-08-33285-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/cab20a06278c/oncotarget-08-33285-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/9f36cf0e4fdf/oncotarget-08-33285-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/3d8ab75e577b/oncotarget-08-33285-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/213d9cae7be8/oncotarget-08-33285-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/bb38ef08f4fb/oncotarget-08-33285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/b4522f5eaf46/oncotarget-08-33285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/77076a2abc0f/oncotarget-08-33285-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/92d88aa8a417/oncotarget-08-33285-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/cab20a06278c/oncotarget-08-33285-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/9f36cf0e4fdf/oncotarget-08-33285-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/3d8ab75e577b/oncotarget-08-33285-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/5464868/213d9cae7be8/oncotarget-08-33285-g008.jpg

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