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iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice.诱导多能干细胞衍生的视网膜移植改善了rd1终末期视网膜变性小鼠的视力。
Stem Cell Reports. 2017 Apr 11;8(4):1112-1113. doi: 10.1016/j.stemcr.2017.03.024.
2
iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice.诱导多能干细胞衍生的视网膜移植改善rd1终末期视网膜变性小鼠的视力。
Stem Cell Reports. 2017 Jan 10;8(1):69-83. doi: 10.1016/j.stemcr.2016.12.008.
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iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice.诱导多能干细胞衍生的视网膜移植改善rd1终末期视网膜变性小鼠的视力。
Stem Cell Reports. 2017 Feb 14;8(2):489. doi: 10.1016/j.stemcr.2017.01.018.
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Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.在缺乏先天性免疫衔接蛋白MyD88的小鼠视网膜变性过程中，光感受器死亡减少，视网膜功能改善。
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Grafted c-kit/SSEA1 eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses.移植的c-kit/SSEA1眼壁祖细胞通过调节神经可塑性和形成新的移植体与宿主突触来延缓小鼠视网膜变性。
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Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice.丙戊酸对Rd1和Rd10视网膜变性小鼠光感受器丧失的不同影响。
Mol Vis. 2014 Nov 4;20:1527-44. eCollection 2014.
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Müller glia express rhodopsin in a mouse model of inherited retinal degeneration.Müller 胶质细胞在遗传性视网膜退行性变的小鼠模型中表达视紫红质。
Neuroscience. 2012 Dec 6;225:152-61. doi: 10.1016/j.neuroscience.2012.08.066. Epub 2012 Sep 9.
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The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration.血管内皮生长因子（VEGF）和血管内皮生长因子受体2/Flk1在小鼠视网膜变性中对视网膜祖细胞增殖的作用
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Alterations in glutamate cysteine ligase content in the retina of two retinitis pigmentosa animal models.两种视网膜色素变性动物模型视网膜中谷氨酸半胱氨酸连接酶含量的改变。
Free Radic Biol Med. 2016 Jul;96:245-54. doi: 10.1016/j.freeradbiomed.2016.04.195. Epub 2016 Apr 30.
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Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse.经典补体激活途径和获得性免疫反应途径对于rd1小鼠的视网膜变性并非必不可少。
Exp Eye Res. 2007 Jan;84(1):82-91. doi: 10.1016/j.exer.2006.08.017. Epub 2006 Oct 25.

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Subretinal microglia support donor photoreceptor survival in rd1 mice.视网膜下小胶质细胞支持 rd1 小鼠供体光感受器的存活。
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Cellular component transfer between photoreceptor cells of the retina.视网膜光感受器细胞之间的细胞成分转移。
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Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole.人多能干细胞源性视网膜片在灵长类动物黄斑裂孔模型中的移植。
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Organoids as preclinical models of human disease: progress and applications.类器官作为人类疾病的临床前模型：进展与应用
Med Rev (2021). 2024 Mar 14;4(2):129-153. doi: 10.1515/mr-2023-0047. eCollection 2024 Apr.
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Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel.人诱导多能干细胞源性光感受器移植于优势眼为 cone 的 13 线地松鼠。
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New Perspectives in Stem Cell Transplantation and Associated Therapies to Treat Retinal Diseases: From Gene Editing to 3D Bioprinting.干细胞移植与相关疗法在视网膜疾病治疗中的新视角：从基因编辑到 3D 生物打印。
Stem Cell Rev Rep. 2024 Apr;20(3):722-737. doi: 10.1007/s12015-024-10689-4. Epub 2024 Feb 6.
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Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases.诱导多能干细胞和类器官在遗传性视网膜疾病中的应用。
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Single-cell transcriptome analysis of xenotransplanted human retinal organoids defines two migratory cell populations of nonretinal origin.单细胞转录组分析鉴定了异种移植人视网膜类器官中的两个非视网膜来源的迁移细胞群体。
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Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions.利用多能干细胞进行光感受器细胞替代：当前认知与遗留问题
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Therapeutic potential of human stem cell transplantations for Vanishing White Matter: A quest for the Goldilocks graft.人源干细胞移植治疗脑白质消融症：寻找合适的移植物。
CNS Neurosci Ther. 2022 Sep;28(9):1315-1325. doi: 10.1111/cns.13872. Epub 2022 Jul 1.

本文引用的文献

1
iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice.诱导多能干细胞衍生的视网膜移植改善rd1终末期视网膜变性小鼠的视力。
Stem Cell Reports. 2017 Jan 10;8(1):69-83. doi: 10.1016/j.stemcr.2016.12.008.
2
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs.利用人类诱导多能干细胞生成具有功能性光感受器的三维视网膜组织。
Nat Commun. 2014 Jun 10;5:4047. doi: 10.1038/ncomms5047.
3
Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets.视网膜祖细胞片植入退化大鼠中的视觉恢复和移植连接。
Eur J Neurosci. 2010 Feb;31(3):508-20. doi: 10.1111/j.1460-9568.2010.07085.x. Epub 2010 Jan 25.
4
Retinal transplants restore visual responses: trans-synaptic tracing from visually responsive sites labels transplant neurons.视网膜移植可恢复视觉反应：来自视觉反应位点的跨突触追踪标记移植神经元。
Eur J Neurosci. 2008 Jul;28(1):208-20. doi: 10.1111/j.1460-9568.2008.06279.x.
5
Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa.视网膜移植诱导色素性视网膜炎啮齿动物模型中视网膜顶盖视觉功能的恢复。
Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1686-95. doi: 10.1167/iovs.02-0615.
6
Retinal transplants restore visually evoked responses in rats with photoreceptor degeneration.视网膜移植可恢复患有光感受器变性的大鼠的视觉诱发反应。
Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1669-76.
7
Light-driven retinal ganglion cell responses in blind rd mice after neural retinal transplantation.神经视网膜移植后盲性rd小鼠中光驱动的视网膜神经节细胞反应
Invest Ophthalmol Vis Sci. 2001 Apr;42(5):1057-65.

iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice.

作者信息

Mandai Michiko, Fujii Momo, Hashiguchi Tomoyo, Sunagawa Genshiro A, Ito Shin-Ichiro, Sun Jianan, Kaneko Jun, Sho Junki, Yamada Chikako, Takahashi Masayo

出版信息

Stem Cell Reports. 2017 Apr 11;8(4):1112-1113. doi: 10.1016/j.stemcr.2017.03.024.

DOI:10.1016/j.stemcr.2017.03.024
PMID:28402835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5883513/
Abstract
摘要