巴伊亚棕油对Triton诱导的血脂异常大鼠的治疗效果。

Effect of the treatment with Euterpe oleracea Mart. oil in rats with Triton-induced dyslipidemia.

作者信息

E Souza Belmira S Faria, Carvalho Helison O, Ferreira Irlon M, da Cunha Edilson L, Barros Albenise Santana, Taglialegna Talisson, Carvalho José C T

机构信息

Laboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e da Saúde, Colegiado de Farmácia, Universidade Federal do Amapá, Rod. JK, KM 02, 68902-280, Macapá, Amapá, Brazil; Programa de Pós-Graduação em Inovação Farmacêutica, Departamento de Ciências Biológicas e da Saúde, Colegiado de Farmácia, Universidade Federal do Amapá, Brazil.

Laboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e da Saúde, Colegiado de Farmácia, Universidade Federal do Amapá, Rod. JK, KM 02, 68902-280, Macapá, Amapá, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Departamento de Ciências Biológicas e da Saúde, Colegiado de Farmácia, Universidade Federal do Amapá, Brazil.

出版信息

Biomed Pharmacother. 2017 Jun;90:542-547. doi: 10.1016/j.biopha.2017.04.005. Epub 2017 Apr 10.

DOI:10.1016/j.biopha.2017.04.005

PMID:28402923

Abstract

OBJECTIVES

Dyslipidemias are defined as changes in lipid metabolism that have abnormal concentrations of lipids or lipoproteins in the bloodstream. Chronic increase in triglyceride and low-density lipoprotein (LDL-c) levels are known as risk factors for the atherogenesis process as well as other cardiovascular diseases (CVDs). The magnitude of the problems caused by dyslipidemias impels research by new agents that act in the prevention and control. Thus, products from the Amazonian biodiversity, such as Euterpe oleracea oil (OFEO), rich in unsaturated fatty acids (UFAs), constitutes a study source for the treatment of alterations in lipid metabolism.

METHODS

The present study aims to investigate the effect of OFEO treatment in rats with Triton-induced dyslipidemia (Tyloxapol WR1339).

RESULTS

The physicochemical and chromatographic results confirmed the chemical composition of OFEO with a predominance of UFAs (67.83%), with Oleic acid being the majority (54.32%). At Triton-induced dyslipidemia, the animals treated with OFEO and Simvastatin showed a significant reduction in total cholesterol levels, with values of 121.7±29.5 (p<0.01) and 96.6±17.6mg/dL (p<0.001), respectively. OFEO also significantly reduced LDL-c levels (p<0.01) and triglycerides (p<0.001). OFEO and Simvastatin improved the lipid profile by significantly increasing (p<0.05) the high-density lipoprotein (HDL) values.

CONCLUSIONS

Therefore, it is concluded that the OFEO treatment used in the conditions of this study had a beneficial effect on dyslipidemia, acting as antihypercholesterolemic and antihypertriglyceridemic, thus possibly contributing as a preventive agent for CVDs.

摘要

目的

血脂异常被定义为脂质代谢的改变，其特征为血液中脂质或脂蛋白浓度异常。甘油三酯和低密度脂蛋白（LDL-c）水平的持续升高是动脉粥样硬化形成过程以及其他心血管疾病（CVD）的已知危险因素。血脂异常所引发问题的严重程度促使人们研发新的预防和控制药物。因此，来自亚马逊生物多样性的产品，如富含不饱和脂肪酸（UFA）的油棕榈果油（OFEO），成为治疗脂质代谢紊乱的研究来源。

方法

本研究旨在探讨OFEO对Triton诱导的血脂异常（泰洛沙泊WR1339）大鼠的治疗效果。

结果

物理化学和色谱分析结果证实了OFEO的化学成分，其中UFA占主导地位（67.83%），油酸含量最高（54.32%）。在Triton诱导的血脂异常模型中，接受OFEO和辛伐他汀治疗的动物总胆固醇水平显著降低，分别为121.7±29.5（p<0.01）和96.6±17.6mg/dL（p<0.001）。OFEO还显著降低了LDL-c水平（p<0.01）和甘油三酯水平（p<0.001）。OFEO和辛伐他汀通过显著提高（p<0.05）高密度脂蛋白（HDL）值改善了血脂谱。