Department of Pharmacy, Laboratório Escola de Farmácia Industrial, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil.
Department of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, I-16145 Genoa, Italy.
Biomolecules. 2020 May 26;10(6):813. doi: 10.3390/biom10060813.
Euterpe oleracea Mart. (EO), popularly known as açaí, belongs to the Arecaceae family and grows abundantly in Brazil. The fruit of this palm tree is widely used because of its anti-inflammatory and antioxidant properties. In this review, a search for literature and patent technological prospecting has been performed on the use of EO to treat and prevent diseases as well as to prepare pharmaceutical formulations. EO leaves, fruits, and oil stand out for their large number of pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, antinociceptive, anticancer, anti-atherogenic, and healing activities, protection against metabolic syndromes such as diabetes, hypertension, and hyperlipidemia, and protection of organs such as lung, kidney, liver, heart, and nervous system. While the phytochemical composition is intrinsically linked to identified biological activities, discoveries of the past decade concerning the use of this species have shown pharmacological alternatives mainly in the treatment and prevention of breast cancer and metabolic syndromes. Although studies and inventions on the use of EO though are believed to have been important in light of the pharmacological activities found, few clinical and toxicity tests have been performed. Nevertheless, with the increase of interest in EO, this species is believed to be only at the beginning of the breakthroughs in the development of promising products for the pharmaceutical industry.
依诺特(Euterpe oleracea Mart.),俗称巴西莓,属于棕榈科,在巴西广泛生长。这种棕榈树的果实因其具有抗炎和抗氧化特性而被广泛应用。在这篇综述中,对使用依诺特治疗和预防疾病以及制备药物制剂进行了文献和专利技术探索。EO 的叶子、果实和油因其具有大量的药理学活性而引人注目,如抗炎、抗氧化、抗菌、抗伤害、抗癌、抗动脉粥样硬化和愈合作用,对代谢综合征(如糖尿病、高血压和高血脂)的保护作用,以及对肺、肾、肝、心和神经系统等器官的保护作用。虽然植物化学成分与已确定的生物活性密切相关,但过去十年对该物种的使用发现表明,药理学替代方法主要在于治疗和预防乳腺癌和代谢综合征。尽管对 EO 的使用进行了研究和发明,鉴于发现的药理学活性,仍很少进行临床和毒性测试。然而,随着对 EO 的兴趣增加,人们相信这种物种在开发有前途的药物产品方面才刚刚开始取得突破。