Luan Xiaoqian, Tao Jingyan, Zhang Jie, Xie Ying, Zhang Xiangyang, Su Hang, He Jincai
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Beijing HuiLongGuan Hospital, Peking University, Beijing, PR China Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Medicine (Baltimore). 2017 Apr;96(15):e6582. doi: 10.1097/MD.0000000000006582.
A growing number of evidence suggests that brain-derived neurotrophic factor (BDNF) plays an important part in modulating the activities on the basis of hippocampus neural plasticity, such as learning and memory. Heroin addiction has a series of cognitive impairments that may be associated with BDNF. In this study, we explored the association of BDNF with cognitive function in heroin-dependent patients.We enrolled 86 heroin-dependent patients and 238 normal control subjects and examined their cognition by the repeatable battery for the assessment of neuropsychological status (RBANS) and serum BDNF levels in 2 groups.BDNF levels were significantly higher in patients than controls (P < .001). Cognitive scores of the RBANS showed that attention and language index (P < .05) were significantly lower in heroin-dependent patients than control groups. Unfortunately, we found no positive association between BDNF and cognitive function in patients, except that BDNF was positively associated with visuospatial/constructional index in control groups.Our findings suggest that BDNF may not be involved in the pathophysiology of heroin dependence, but more studies about cognitive impairment in heroin addiction are needed.
越来越多的证据表明，脑源性神经营养因子（BDNF）在基于海马神经可塑性调节诸如学习和记忆等活动中发挥重要作用。海洛因成瘾有一系列可能与BDNF相关的认知障碍。在本研究中，我们探讨了BDNF与海洛因依赖患者认知功能的关联。我们招募了86名海洛因依赖患者和238名正常对照受试者，并通过可重复成套神经心理状态评估量表（RBANS）对两组受试者的认知功能进行检查，并检测血清BDNF水平。患者的BDNF水平显著高于对照组（P<0.001）。RBANS的认知评分显示，海洛因依赖患者的注意力和语言指数（P<0.05）显著低于对照组。遗憾的是，我们发现患者中BDNF与认知功能之间无正相关，仅在对照组中BDNF与视觉空间/结构指数呈正相关。我们的研究结果表明，BDNF可能不参与海洛因依赖的病理生理过程，但仍需要更多关于海洛因成瘾认知障碍的研究。
