BDNF 水平低与 2 型糖尿病患者的认知功能障碍有关。
Low BDNF is associated with cognitive deficits in patients with type 2 diabetes.
机构信息
Department of Internal Medicine, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
出版信息
Psychopharmacology (Berl). 2013 May;227(1):93-100. doi: 10.1007/s00213-012-2942-3. Epub 2012 Dec 22.
OBJECTIVE
Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated.
MATERIALS AND METHODS
We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
RESULTS
Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (p < 0.001). The total score and nearly all indexes (all p < 0.01) except for attention and visuospatial/constructional indexes (all p > 0.05) of RBANS were markedly lower in T2DM than controls. There was a positive relationship between serum BDNF and delayed memory in patients with T2DM.
CONCLUSION
Our results suggest that BDNF may play a role in the pathophysiology of cognitive deficits, especially delayed memory in T2DM.
目的
有研究表明脑源性神经营养因子（BDNF）在调节海马体与记忆相关的神经可塑性方面发挥着重要作用。2 型糖尿病（T2DM）与认知功能的多个领域受损有关，这可能是由于 BDNF 减少所致；然而，BDNF 与 T2DM 认知障碍的相关性尚未得到研究。
材料和方法
我们将 208 例 T2DM 患者与 212 例正常对照者的血清 BDNF 和重复性成套神经心理状态评估量表（RBANS）进行了比较。
结果
与正常对照组相比，T2DM 患者的血清 BDNF 水平显著降低（p<0.001）。除注意力和视空间/结构指数外（均 p>0.05），T2DM 患者的 RBANS 总评分和几乎所有指数（均 p<0.01）均显著低于对照组。在 T2DM 患者中，血清 BDNF 与延迟记忆呈正相关。
结论
我们的结果表明，BDNF 可能在 T2DM 认知功能障碍的病理生理学中发挥作用，尤其是在延迟记忆方面。
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