He S C, Zhang Y Y, Zhan J Y, Wang C, Du X D, Yin G Z, Cao B, Ning Y P, Soares J C, Zhang X Y
School of Psychological and Cognitive Sciences, Peking University, Beijing, China.
Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Psychoneuroendocrinology. 2017 Mar;77:236-243. doi: 10.1016/j.psyneuen.2017.01.002. Epub 2017 Jan 10.
Some studies have demonstrated that subjects with chronic burnout showed cognitive impairments; however, cognitive performance in burnout has been under-investigated. Increasing evidence show that brain-derived neurotrophic factor (BDNF) plays a critical role in cognitive function. We hypothesized that decreased BDNF may be associated with cognitive impairments in burnout, which has not been investigated yet. The aim of the present study was to examine the association of BDNF with cognitive impairment in burnout.
Using a cross-sectional design, 712 healthy subjects were recruited from a general hospital and they were all measured with the Maslach Burnout Inventory (MBI). We assessed part of subjects on the repeatable battery for the assessment of neuropsychological status (RBANS) (n=192) and serum BDNF levels (n=127).
30.5% of the subjects had burnout. Compared to those non-burnout subjects, the burnout subjects were younger, had significant lower BDNF levels (p=0.003) and scored lower on immediate memory, RBANS total score and attention (all p<0.05). Interestingly, after the Bonferroni correction, there were negative correlations between BDNF and MBI total score or reduced professional accomplishment (PA). Moreover, BDNF was positively associated with immediate memory, attention and RBANS total score. Further multiple regression analysis showed that BDNF was an independent contributor to the RBANS total score and attention, and BDNF and MBI depersonalization (DP) were independent contributors to immediate memory. In addition, there was mediating effect of BDNF in the relation between burnout and cognitive impairments.
Our results suggest that burnout is associated with significant cognitive impairments and decreased BDNF. Moreover, decreased BDNF is associated with cognitive impairments in burnout.
一些研究表明，患有慢性职业倦怠的受试者存在认知障碍；然而，职业倦怠中的认知表现尚未得到充分研究。越来越多的证据表明，脑源性神经营养因子（BDNF）在认知功能中起关键作用。我们假设BDNF降低可能与职业倦怠中的认知障碍有关，而这一点尚未得到研究。本研究的目的是探讨BDNF与职业倦怠中认知障碍的关系。
采用横断面设计，从一家综合医院招募了712名健康受试者，并用马氏职业倦怠量表（MBI）对他们进行测量。我们对部分受试者进行了可重复神经心理状态评估量表（RBANS）（n = 192）和血清BDNF水平（n = 127）的评估。
30.5%的受试者存在职业倦怠。与无职业倦怠的受试者相比，职业倦怠受试者更年轻，BDNF水平显著更低（p = 0.003），在即时记忆、RBANS总分和注意力方面得分更低（均p < 0.05）。有趣的是，经过Bonferroni校正后，BDNF与MBI总分或职业效能降低（PA）之间存在负相关。此外，BDNF与即时记忆、注意力和RBANS总分呈正相关。进一步的多元回归分析表明，BDNF是RBANS总分和注意力的独立影响因素，BDNF和MBI去个性化（DP）是即时记忆的独立影响因素。此外，BDNF在职业倦怠与认知障碍的关系中起中介作用。
我们的结果表明，职业倦怠与显著的认知障碍和BDNF降低有关。此外，BDNF降低与职业倦怠中的认知障碍有关。
