Huan Yanmei, Qi Yiwei, Zhang Weisheng, Chu Jianguo
Department of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Medicine (Baltimore). 2017 Apr;96(15):e6603. doi: 10.1097/MD.0000000000006603.
Primary bone lymphoma (PBL) is a rare malignant entity. There is a better survival of PBL than any other malignant bone tumors and extranodal lymphomas.
We report a rare case of PBL involving radius and tibia. The patient was a 14-year-old girl with left forearm pain and swelling after trauma. Six months later after the last chemotherapy and radiotherapy, pain and swelling of left knee was presented.
Radiological imaging revealed a lytic destruction, periosteal reaction, and pathological fracture of radius and tibia with soft tissue mass. Surgical biopsy was performed, and the result of histopathological diagnosis was diffused large B-cell lymphoma (stage IV, group A).
Chemotherapy combined with radiotherapy was applied before curation.
Due to its uncommon presentation, PBL should be taken into consideration if differential diagnosis from other bone tumors is necessary in clinic.
原发性骨淋巴瘤（PBL）是一种罕见的恶性实体瘤。与其他任何恶性骨肿瘤和结外淋巴瘤相比，PBL患者的生存率更高。
我们报告一例罕见的累及桡骨和胫骨的PBL病例。该患者为一名14岁女孩，外伤后出现左前臂疼痛和肿胀。在最后一次化疗和放疗6个月后，出现左膝疼痛和肿胀。
影像学检查显示桡骨和胫骨有溶骨性破坏、骨膜反应及病理性骨折，并伴有软组织肿块。进行了手术活检，组织病理学诊断结果为弥漫性大B细胞淋巴瘤（IV期，A组）。
在治疗前采用了化疗联合放疗。
由于其临床表现不常见，临床上在需要与其他骨肿瘤进行鉴别诊断时应考虑到PBL。
