Stoddard Marie Alexia, Herrmann Jennifer, Moy Lauren, Moy Ronald
J Drugs Dermatol. 2017 Apr 1;16(4):322-326.
BACKGROUND: Atrophic scarring in skin of color is a common, permanent, and distressing result of uncontrolled acne vulgaris. Ablative lasers and chemical peels are frequently used to improve the appearance of atrophic scars, primarily through the stimulation of collagen and elastin; however, these treatment modalities are associated with risks, such as dyspigmentation and hypertrophic scarring, especially in patients with darker skin.
OBJECTIVE: We evaluated the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color.
METHODS: A single-center clinical trial was performed on twelve healthy men and women (average age 32.5) with Fitzpatrick Type IV-V skin and evidence of facial grade II-IV atrophic acne scars. Subjects applied topical EGF serum to the full-face twice daily for 12 weeks. Scar improvement was investigated at each visit using an Investigator Global Assessment (IGA), a Goodman grade, clinical photography, and patient self-assessment.
RESULTS: Eleven subjects completed the trial. Compared to baseline, there was an improvement in mean IGA score from 3.36 (SEM = 0.15) to 2.18 (SEM = 0.33). Mean Goodman grade was reduced from 2.73 (SEM = 0.19) to 2.55 (SEM = 0.21). Of the eleven pairs of before and after photographs, nine were correctly chosen as the post-treatment image by a blind investigator. On self-assessment, 81% reported a "good" to "excellent" improvement in their scars compared to baseline (P = 0.004).
CONCLUSION: Topical EGF may improve the appearance of atrophic acne scars in skin of color. Additional, larger studies should be conducted to better characterize improvement.
J Drugs Dermatol. 2017;16(4):322-326.
.寻常痤疮若未得到控制，会在有色人种皮肤上形成萎缩性瘢痕，这是一种常见、永久性且令人苦恼的后果。剥脱性激光和化学剥脱术常被用于改善萎缩性瘢痕的外观，主要是通过刺激胶原蛋白和弹性蛋白；然而，这些治疗方式存在风险，如色素沉着和增生性瘢痕，尤其是在肤色较深的患者中。
我们评估了局部应用合成表皮生长因子（EGF）血清减少有色人种皮肤萎缩性痤疮瘢痕外观的疗效。
对12名健康男性和女性（平均年龄32.5岁）进行了一项单中心临床试验，这些受试者的皮肤类型为Fitzpatrick IV - V型，面部有II - IV级萎缩性痤疮瘢痕。受试者每天两次将局部EGF血清涂抹于全脸，持续12周。每次就诊时使用研究者整体评估（IGA）、古德曼分级、临床照片和患者自我评估来调查瘢痕改善情况。
11名受试者完成了试验。与基线相比，平均IGA评分从3.36（标准误 = 0.15）改善至2.18（标准误 = 0.33）。平均古德曼分级从2.73（标准误 = 0.19）降至2.55（标准误 = 0.21）。在11组前后照片中，有9组被一位盲法研究者正确选为治疗后的图像。自我评估显示，81%的受试者报告其瘢痕与基线相比有“良好”到“优秀”的改善（P = 0.004）。
局部应用EGF可能改善有色人种皮肤萎缩性痤疮瘢痕的外观。应开展更多、规模更大的研究以更好地描述改善情况。
《皮肤药物学杂志》2017年；16(4):322 - 326。
