Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey.
Marmara University, Faculty of Dentistry, Department of Biochemistry, Istanbul, Turkey.
J Appl Oral Sci. 2017 Mar-Apr;25(2):211-216. doi: 10.1590/1678-77572015-0187.
To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction.
Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups.
HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group.
Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions.
探讨透明质酸（HA）对第三磨牙拔除后出血及相关结局的影响。
40 例接受磨牙拔除术的患者随机分为两组；HA 组（n=20）应用 0.8%（w/v）HA，对照组（n=20）未治疗。比较两组的唾液和牙龈组织因子（TF）水平、出血时间、最大切牙开口（MIO）、视觉模拟评分法（VAS）疼痛评分和肿胀程度。
HA 对牙龈 TF 水平无显著影响。HA 应用后 1 周唾液 TF 水平显著升高，但对照组无此变化。两组 VAS 疼痛评分和 MIO 无显著差异。HA 组术后第 3 天肿胀程度和出血时间大于对照组。
0.8%HA 局部注射可延长出血时间，并增加第三磨牙拔除后早期的出血和肿胀。
