Pypendop Bruno H, Verstegen John P
Department of Small Animal Reproduction, School of Veterinary Medicine, University of Liege, Liege, Belgium.
Vet Anaesth Analg. 2000 Jan;27(1):36-44. doi: 10.1046/j.1467-2995.2000.00003.x. Epub 2016 Nov 15.
To obtain renal cortical, ileal, colonic and skeletal muscle microvascular blood flow measurements in dogs using the laser Doppler technique and to characterize the effects of medetomidine-midazolam-butorphanol combination on these flows.
Prospective randomized experimental study.
Fourteen clinically normal beagles (two groups of seven), aged 1-4 years and weighing 13.2 ± 1.8 kg.
All dogs were anaesthetized with 1.7% end-tidal isoflurane in oxygen. In the treatment group, after instrumentation and when anaesthesia was considered stable, medetomidine (1 mg m body surface area (BSA)) was administered intramuscularly (time 0). Midazolam (1 mg kg) and butorphanol (0.1 mg kg) were administered intravenously 20 minutes later. Atipamezole (2.5 mg m BSA) was administered intramuscularly 60 minutes after medetomidine. In the control group, saline (0.5, 2.5 and 0.25 mL) was administered at the corresponding times. Heart rate, systolic, diastolic and mean arterial pressures, body temperature, renal cortical, ileal, colonic and skeletal muscle microvascular blood flows were measured before time 0, and 5, 15, 25, 40, 60, 65, 70 and 90 minutes thereafter.
Heart rate, ileal and skeletal muscle blood flows decreased in the treatment group, while no changes were observed in the control group.
Laser Doppler flowmetry allowed the measurement of microvascular blood flow in different organs. The medetomidine-midazolam-butorphanol combination decreases intestinal and skeletal muscle microvascular blood flows, while renal cortical blood flow is maintained.
Medetomidine-midazolam-butorphanol combination can be used to induce a short duration anaesthesia in dogs, but it will induce cardiovascular depression. This depression appears to be accompanied by a redistribution of blood flow.
使用激光多普勒技术测量犬肾皮质、回肠、结肠和骨骼肌的微血管血流，并描述美托咪定 - 咪达唑仑 - 布托啡诺组合对这些血流的影响。
前瞻性随机实验研究。
14只临床健康的比格犬（两组，每组7只），年龄1 - 4岁，体重13.2 ± 1.8千克。
所有犬均用1.7%的呼气末异氟醚在氧气中麻醉。在治疗组，仪器安装后且麻醉稳定时，肌肉注射美托咪定（1毫克/米²体表面积（BSA））（时间0）。20分钟后静脉注射咪达唑仑（1毫克/千克）和布托啡诺（0.1毫克/千克）。美托咪定注射60分钟后肌肉注射阿替美唑（2.5毫克/米²BSA）。在对照组，在相应时间注射生理盐水（0.5、2.5和0.25毫升）。在时间0之前以及之后的5、15、25、40、60、65、70和90分钟测量心率、收缩压、舒张压和平均动脉压、体温、肾皮质、回肠、结肠和骨骼肌的微血管血流。
治疗组心率、回肠和骨骼肌血流下降，而对照组未观察到变化。
激光多普勒血流仪可测量不同器官的微血管血流。美托咪定 - 咪达唑仑 - 布托啡诺组合可降低肠道和骨骼肌的微血管血流，同时维持肾皮质血流。
美托咪定 - 咪达唑仑 - 布托啡诺组合可用于诱导犬的短期麻醉，但会引起心血管抑制。这种抑制似乎伴随着血流的重新分布。
