Shafford Heidi L, Hellyer Peter W, Crump Kenneth T, Wagner Ann E, Mama Khursheed R, Gaynor James S
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, USA.
Vet Anaesth Analg. 2002 Jan;29(1):43-48. doi: 10.1046/j.1467-2987.2001.00072.x. Epub 2016 Nov 15.
To determine if pulsed electromagnetic field (PEMF) therapy reduces post-operative pain in dogs following ovariohysterectomy, and to evaluate PEMF interaction with post-operative morphine analgesia.
Randomized controlled clinical trail.
Sixteen healthy dogs weighing 18 (10-32) kg [median (range)] and aged 13 (3-36) months.
Anesthesia consisted of atropine (0.04 mg kg, SC), acepromazine (0.02 mg kg, SC), fentanyl (0.01 mg kg, SC), thiopental (10-15 mg kg, IV) and halothane in oxygen. Ovariohysterectomies were performed by senior veterinary students. Pain score (numeric rating scale, 0-28), pulse rate, respiratory rate, indirect mean arterial pressure (MAP), and body temperature were evaluated prior to anesthetic premedication, at extubation, 30 minutes after extubation, and then hourly for 6 hours. Following extubation, dogs were randomly divided into four groups: a control group that received 0.9% NaCl, IV, and no PEMF; a magnet group that received 0.9% NaCl, IV, and PEMF; a morphine group that received morphine 0.25 mg kg, IV, and no PEMF; and, a magnet/morphine group that received morphine 0.25 mg kg, IV, and PEMF. A single observer, blinded to treatment, obtained all behavioral observations and physiologic data. Data were analyzed using the Kruskal-Wallis statistical test with a significance of p < 0.05.
Significant differences in MAP (mm Hg) [median (range)] occurred at 300 minutes [morphine 108 (83-114) and magnet/morphine 90 (83-97) < magnet 135 (113-117)], and at 360 minutes [magnet/morphine 93 (81-100) < control 127 (111-129) and magnet 126 (111-129)]. At 30 minutes the total pain score for the magnet/morphine group [1.5 (0-5)] was significantly less than control [8 (6-13)], but not different from magnet [5.5 (4-7)] or morphine [4.5 (2-9)].
Although no clear benefit was seen in this study, the results suggest that PEMF may augment morphine analgesia following ovariohysterectomy in dogs, and that further study of the analgesic effects of PEMF is warranted.
确定脉冲电磁场（PEMF）疗法是否能减轻犬卵巢子宫切除术后的疼痛，并评估PEMF与术后吗啡镇痛的相互作用。
随机对照临床试验。
16只健康犬，体重18（10 - 32）千克[中位数（范围）]，年龄13（3 - 36）个月。
麻醉用药包括阿托品（0.04毫克/千克，皮下注射）、乙酰丙嗪（0.02毫克/千克，皮下注射）、芬太尼（0.01毫克/千克，皮下注射）、硫喷妥钠（10 - 15毫克/千克，静脉注射）以及氧气中的氟烷。卵巢子宫切除术由资深兽医专业学生实施。在麻醉前用药前、拔管时、拔管后30分钟，然后每小时评估一次，共评估6小时，评估指标包括疼痛评分（数字评分量表，0 - 28）、脉搏率、呼吸率、间接平均动脉压（MAP）和体温。拔管后，犬被随机分为四组：对照组静脉注射0.9%氯化钠溶液，不接受PEMF治疗；磁疗组静脉注射0.9%氯化钠溶液，并接受PEMF治疗；吗啡组静脉注射0.25毫克/千克吗啡，不接受PEMF治疗；磁疗/吗啡组静脉注射0.25毫克/千克吗啡，并接受PEMF治疗。由一名对治疗不知情的观察者获取所有行为观察结果和生理数据。使用Kruskal - Wallis统计检验分析数据，显著性水平为p < 0.05。
MAP（毫米汞柱）[中位数（范围）]在300分钟时出现显著差异[吗啡组108（83 - 114）和磁疗/吗啡组90（83 - 97）<磁疗组135（113 - 117）]，以及在360分钟时出现显著差异[磁疗/吗啡组93（81 - 100）<对照组127（111 - 129）和磁疗组126（111 - 129）]。在30分钟时，磁疗/吗啡组的总疼痛评分[1.5（0 - 5）]显著低于对照组[8（6 - 13）]，但与磁疗组[5.5（4 - 7）]或吗啡组[4.5（2 - 9）]无差异。
尽管本研究未观察到明显益处，但结果表明PEMF可能增强犬卵巢子宫切除术后的吗啡镇痛效果，因此有必要进一步研究PEMF的镇痛作用。
