Miller Alyssa J, Spence Jason R
PhD Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
Physiology (Bethesda). 2017 May;32(3):246-260. doi: 10.1152/physiol.00041.2016.
The main function of the lung is to support gas exchange, and defects in lung development or diseases affecting the structure and function of the lung can have fatal consequences. Most of what we currently understand about human lung development and disease has come from animal models. However, animal models are not always fully able to recapitulate human lung development and disease, highlighting an area where in vitro models of the human lung can compliment animal models to further understanding of critical developmental and pathological mechanisms. This review will discuss current advances in generating in vitro human lung models using primary human tissue, cell lines, and human pluripotent stem cell derived lung tissue, and will discuss crucial next steps in the field.
肺的主要功能是支持气体交换，肺发育缺陷或影响肺结构与功能的疾病可能会产生致命后果。我们目前对人类肺发育和疾病的大部分了解都来自动物模型。然而，动物模型并不总是能够完全重现人类肺发育和疾病情况，这凸显出人类肺体外模型可以补充动物模型，以进一步了解关键发育和病理机制的领域。本综述将讨论使用原代人体组织、细胞系和人多能干细胞衍生的肺组织生成体外人肺模型的当前进展，并将讨论该领域关键的下一步措施。
