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lncRNA H19基因多态性与癌症易感性之间的显著关联：一项荟萃分析。

Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis.

作者信息

Li Xue-Feng, Yin Xin-Hai, Cai Jun-Wei, Wang Ming-Ju, Zeng Yu-Qin, Li Min, Niu Yu-Ming, Shen Ming

机构信息

Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.

Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's Hospital, Guiyang 550000, China.

出版信息

Oncotarget. 2017 Jul 11;8(28):45143-45153. doi: 10.18632/oncotarget.16658.

DOI:10.18632/oncotarget.16658
PMID:28404885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5542173/
Abstract

Previous epidemiological research suggests polymorphisms in long non-coding RNA (lncRNA) H19 are associated with an increased risk of cancer, but the results are inconsistent. We therefore conducted a meta-analysis to more accurately determine the association between lncRNA H19 polymorphisms and cancer risk. The PubMed, Embase, and Science Citation Index online databases were searched and 11 relevant studies involving a total of 33,209 participants were identified. Odds ratios (ORs) and corresponding 95% confidence interval (CIs) from these studies were used to detect associations between H19 polymorphisms and cancer risk using five genetic models. The pooled result suggested that the rs2839698 G>A polymorphism was associated with digestive cancer risk in all five models. Moreover, a protective effect against cancer development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations. No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk. In summary, the rs2839698 G>A and rs2107425 C>T polymorphisms in lncRNA H19 may therefore play opposing roles during cancer development, and their effects may vary depending on cancer type and patient ethnicity.

摘要

先前的流行病学研究表明，长链非编码RNA（lncRNA）H19中的多态性与癌症风险增加相关，但结果并不一致。因此，我们进行了一项荟萃分析，以更准确地确定lncRNA H19多态性与癌症风险之间的关联。检索了PubMed、Embase和科学引文索引在线数据库，确定了11项相关研究，共涉及33209名参与者。这些研究中的优势比（OR）和相应的95%置信区间（CI）用于通过五种遗传模型检测H19多态性与癌症风险之间的关联。汇总结果表明，rs2839698 G>A多态性在所有五种模型中均与消化系统癌症风险相关。此外，观察到rs2107425 C>T多态性的T等位基因变体对癌症发生具有保护作用，尤其是在白种人患者群体中。未发现lncRNA H19 rs217727 G>A多态性与癌症风险之间存在显著关联。总之，lncRNA H19中的rs2839698 G>A和rs2107425 C>T多态性在癌症发生过程中可能发挥相反作用，其影响可能因癌症类型和患者种族而异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/c54de4af23a6/oncotarget-08-45143-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/01f9e3721942/oncotarget-08-45143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/5316cf9f56e2/oncotarget-08-45143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/fa646dd83f60/oncotarget-08-45143-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/e74fe2f325b8/oncotarget-08-45143-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/c54de4af23a6/oncotarget-08-45143-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/01f9e3721942/oncotarget-08-45143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/5316cf9f56e2/oncotarget-08-45143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/fa646dd83f60/oncotarget-08-45143-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/e74fe2f325b8/oncotarget-08-45143-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/5542173/c54de4af23a6/oncotarget-08-45143-g005.jpg

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