Lu Yanjun, Tan Lu, Shen Na, Peng Jing, Wang Chunyu, Zhu Yaowu, Wang Xiong
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.
Oncotarget. 2016 Sep 13;7(37):59580-59588. doi: 10.18632/oncotarget.10936.
Reports on the relationship between the lncRNA H19 rs217727 polymorphism and the risk of cancer in the Chinese population have been inconsistent. Therefore, we performed a meta-analysis to evaluate this association, by searching the Embase, PubMed, Web of Science, Wanfang, and CNKI databases. Four case-control studies with 3,157 cases and 3,564 controls were selected for this meta-analysis. The odds ratios with 95% confidence intervals were examined using the random effect model. Allelic (A vs. G), dominant (AA + GA vs. GG), recessive (AA vs. GA + GG), and additive (AA vs. GG) genetic models were used to determine the association. Overall, no significant association was observed between the rs217727 polymorphism and cancer susceptibility in any of the four genetic models. Sensitivity analysis revealed that the results were stable in the allelic and dominant genetic models, but those from the recessive and additive models were unstable, which should be treated with caution. Our meta-analysis suggests that the lncRNA H19 rs217727 polymorphism might not be associated with overall cancer risk. However, well-designed, large-scale studies with different ethnic populations need to be conducted in the future to elucidate the potential association.
关于lncRNA H19 rs217727多态性与中国人群癌症风险之间关系的报道并不一致。因此，我们通过检索Embase、PubMed、Web of Science、万方和知网数据库进行了一项荟萃分析，以评估这种关联。本荟萃分析选取了四项病例对照研究，共3157例病例和3564例对照。采用随机效应模型检验比值比及95%置信区间。采用等位基因（A对G）、显性（AA + GA对GG）、隐性（AA对GA + GG）和加性（AA对GG）遗传模型来确定关联性。总体而言，在四种遗传模型中的任何一种中，均未观察到rs217727多态性与癌症易感性之间存在显著关联。敏感性分析显示，等位基因和显性遗传模型的结果稳定，但隐性和加性模型的结果不稳定，应谨慎对待。我们的荟萃分析表明，lncRNA H19 rs217727多态性可能与总体癌症风险无关。然而，未来需要开展设计良好的针对不同种族人群的大规模研究，以阐明潜在的关联。
