Hashemi Mohammad, Moazeni-Roodi Abdolkarim, Sarabandi Sahel, Karami Shima, Ghavami Saeid
Genetics of Non-communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan 9816743181, Iran.
J Genet. 2019 Sep;98.
Long noncoding RNA (lncRNA) H19, a well-known oncogenic lncRNA, is overexpressed in various cancers. Several studies have investigated the association between polymorphisms in lncRNA H19 and the risk of various cancer types; however, the findings were inconsistent. In this study, we performed a meta-analysis to identify the precise association between H19 polymorphisms and cancer risk. Appropriate studies were retrieved from searching Web of Science, PubMed, Scopus, and Google scholar databases, updated 25 November 2018. The pooled odds ratios (ORs with 95% confidence intervals (CIs) were calculated to estimate the strength of the association between H19 polymorphisms and cancer risk. Our findings revealed that the H19-rs217727 C>T polymorphism is significantly associated with an increased risk of overall cancer in homozygous codominant (OR=1.28, 95% CI=1.04-1.57, =0.020, TT vs CC), dominant (OR=1.20, 95% CI=1.04-1.37, =0.010, CT+TT vs CC), recessive (OR=1.21, 95% CI=1.00-1.46, =0.048, TT vs CT+CC), and allele (OR=1.16, 95% CI=1.05-1.28, =0.003, T vs C) genetic models. No significant correlations were observed between H19: rs2839698 G>A, rs2107425 C>T, rs2735971 C>T, rs3024270 G>C, rs3741219 T>C, rs2839701 C>G, rs2735469 C>T, rs17658052 G>A, and rs3741216 T>A polymorphisms and overall cancer risk. Stratified analysis by cancer type proposed that the rs217727 variant is associated with increased risk of oral squamous cell carcinoma (OSCC) and lung cancer, whereas the rs2839698 variant is associated with increased risk of gastrointestinal cancer. Taken together, these findings support an association between H19 rs217727, and rs2839698 polymorphisms and cancer susceptibility. Larger and well-designed studies are necessary to further confirm these findings in detail.
长链非编码RNA（lncRNA）H19是一种著名的致癌lncRNA，在多种癌症中均有过表达。多项研究调查了lncRNA H19多态性与各种癌症类型风险之间的关联；然而，研究结果并不一致。在本研究中，我们进行了一项荟萃分析，以确定H19多态性与癌症风险之间的确切关联。通过检索科学网、PubMed、Scopus和谷歌学术数据库获取合适的研究，检索时间更新至2018年11月25日。计算合并优势比（OR值及95%置信区间（CI））以评估H19多态性与癌症风险之间关联的强度。我们的研究结果显示，H19-rs217727 C>T多态性在纯合共显性（OR=1.28，95%CI=1.04-1.57，P=0.020，TT与CC相比）、显性（OR=1.20，95%CI=1.04-1.37，P=0.010，CT+TT与CC相比）、隐性（OR=1.21，95%CI=1.00-1.46，P=0.048，TT与CT+CC相比）以及等位基因（OR=1.16，95%CI=1.05-1.28，P=0.003，T与C相比）遗传模型中均与总体癌症风险增加显著相关。未观察到H19的rs2839698 G>A、rs2107425 C>T、rs2735971 C>T、rs3024270 G>C、rs3741219 T>C、rs2839701 C>G、rs2735469 C>T、rs17658052 G>A和rs3741216 T>A多态性与总体癌症风险之间存在显著相关性。按癌症类型进行的分层分析表明，rs217727变异与口腔鳞状细胞癌（OSCC）和肺癌风险增加相关，而rs2839698变异与胃肠道癌症风险增加相关。综上所述，这些研究结果支持H19 rs217727和rs2839698多态性与癌症易感性之间存在关联。需要开展更大规模且设计良好的研究以进一步详细证实这些研究结果。
