Benediktsdottir V E, Gudbjarnason S
University of Iceland, Science Institute, Reykjavik.
J Mol Cell Cardiol. 1988 Feb;20(2):141-7. doi: 10.1016/s0022-2828(88)80027-0.
The effect of dietary cod liver oil, corn oil or butter upon the lipid composition of cardiac sarcolemma and the activity of sarcolemmal Na+, K+ ATPase was examined in male Wistar rats. The cod liver oil diet caused significant changes in the fatty acid composition of the major phospholipids of sarcolemma, phosphatidyl choline and phosphatidyl ethanolamine. In both these phospholipids arachidonic acid, 20:4 (n - 6) was reduced by about 50% compared to rats fed butter or corn oil and was replaced by the (n - 3) fatty acids eicosapentaenoic and docosahexaenoic acids. The corn oil diet caused a significant diminution in the oleic acid content of phosphatidyl choline and elevation of linoleic acid in phosphatidyl ethanolamine. The phospholipid class composition, total phospholipid fatty acid content and cholesterol content of sarcolemma were not altered by the diets used. The activity of Na+, K+ ATPase in the cardiac sarcolemma was not significantly changed by the different diets.
在雄性Wistar大鼠中，研究了膳食中的鱼肝油、玉米油或黄油对心肌肌膜脂质组成以及肌膜Na⁺、K⁺ - ATP酶活性的影响。鱼肝油饮食导致肌膜主要磷脂（磷脂酰胆碱和磷脂酰乙醇胺）的脂肪酸组成发生显著变化。与喂食黄油或玉米油的大鼠相比，在这两种磷脂中，花生四烯酸（20:4，n - 6）减少了约50%，并被（n - 3）脂肪酸二十碳五烯酸和二十二碳六烯酸所取代。玉米油饮食导致磷脂酰胆碱中油酸含量显著降低，磷脂酰乙醇胺中亚油酸含量升高。所用饮食未改变肌膜的磷脂类组成、总磷脂脂肪酸含量和胆固醇含量。不同饮食对心肌肌膜中Na⁺、K⁺ - ATP酶的活性没有显著影响。
