Giunchi Francesca, Jordahl Kristina, Bollito Enrico, Colecchia Maurizio, Patriarca Carlo, D'Errico Antonietta, Vasuri Francesco, Malvi Deborah, Fornari Alessandro, Bonetti Luca Reggiani, Corti Barbara, Papotti Mauro, DeGiuli Paolo, Loda Massimo, Montironi Rodolfo, Fiorentino Michelangelo, Rider Jennifer R
Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Viale Ercolani 4/2, 40138, Bologna, Italy.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 677 Avenue, Huntington, MA, 02115, USA.
Virchows Arch. 2017 Jun;470(6):711-715. doi: 10.1007/s00428-017-2123-1. Epub 2017 Apr 12.
Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.
流行病学和生物学证据表明，增殖性萎缩性病变的存在与前列腺上皮内瘤变（PIN）及前列腺癌的发生之间存在因果关系。前列腺的炎症性和萎缩性病变的存在被广泛低估，且病理报告中通常未提及。我们让八位泌尿生殖专科医生和七位普通病理学家对116张前列腺病变组织学切片（包括增殖性萎缩性病变、PIN和癌症）进行了组织病理学一致性研究。所有可能的评审员对之间对于前列腺癌的总体一致性为80%，对于PIN为67%，对于增殖性萎缩性病变为49%。当以一位泌尿生殖病理学家的评估作为金标准时，前列腺癌的平均一致性百分比增至97%，PIN为92%，增殖性萎缩性病变为72%。
