Chung Min-Ching, Chan Yung-Hsiang, Chang Wen-Jung, Hou Duen-Ren
Department of Chemistry, National Central University, No. 300 Jhong-Da Rd., Jhong-li, Taoyuan, Taiwan32001.
Org Biomol Chem. 2017 May 3;15(17):3783-3790. doi: 10.1039/c7ob00528h.
Hydroamination of 3-butynamine derivatives to give non-aromatic 2,3-dihydropyrroles was achieved by using PdCl or AuCl as the catalyst. With microwave-assisted heating, up to 92% isolated yield was obtained from this intramolecular 5-endo-dig cyclisation. The cyclopentane- and cyclohexane-fused 2,3-dihydropyrroles were transformed into the corresponding N-tosyl-pyrrolidine-2-carboxylic acids.
