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维生素D受体基因多态性与败血症风险及死亡率的关联

Vitamin D receptor gene polymorphisms association with the risk of sepsis and mortality.

作者信息

Zeljic K, Elkilany A, Supic G, Surbatovic M, Djordjevic D, Magic Z, Bozic B

机构信息

Faculty of Biology, University of Belgrade, Belgrade, Serbia.

Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.

出版信息

Int J Immunogenet. 2017 Jun;44(3):129-134. doi: 10.1111/iji.12318. Epub 2017 Apr 12.

DOI:10.1111/iji.12318
PMID:28406554
Abstract

Association of vitamin D receptor (VDR) gene polymorphisms with sepsis risk and mortality was studied. VDR FokI CC genotype was associated with increased sepsis risk (OR = 13.396, p = .000009) compared to the TT genotype. Results suggest possible role of VDR FokI (rs2228570) as a molecular biomarker of increased sepsis risk.

摘要

研究了维生素D受体（VDR）基因多态性与败血症风险及死亡率之间的关联。与TT基因型相比，VDR FokI CC基因型与败血症风险增加相关（OR = 13.396，p = 0.000009）。结果表明VDR FokI（rs2228570）可能作为败血症风险增加的分子生物标志物发挥作用。

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