Karriker-Jaffe Katherine J, Ji Jianguang, Sundquist Jan, Kendler Kenneth S, Sundquist Kristina
Alcohol Research Group, Public Health Institute, Emeryville, CA, USA.
Center for Primary Health Care Research, Lund University, Malmö, Sweden.
Addiction. 2017 Aug;112(8):1386-1394. doi: 10.1111/add.13834. Epub 2017 May 16.
Pharmacotherapy can be an important part of the continuum of care for alcohol use disorder (AUD). The Swedish universal health-care system emphasizes provision of care to marginalized groups. The primary aim was to test associations of neighborhood deprivation and disadvantaged social status with receipt of AUD pharmacotherapy in this context.
Data from linked population registers were used to follow an open cohort over 7 years.
Sweden.
Alcohol-related ICD-10 codes reported for all hospitalizations in the Swedish Hospital Discharge Register and all clinic/office visits in the Outpatient Care Register between 2005 and 2012 were used to identify 62 549 cases with AUD.
The primary outcome was any AUD pharmacotherapy (naltrexone, disulfiram, acamprosate, nalmefene) picked up by patients between 2005 and 2012 (versus none), based on the Swedish Prescribed Drug Register. Neighborhood deprivation was defined using aggregated data from the Total Population Register; indicators of disadvantaged social status (income, education, country of origin) also came from this source.
Approximately half the cases (53.7%) picked up one or more AUD pharmacotherapy prescriptions. In adjusted models, people living in neighborhoods with moderate [odds ratio (OR) = 0.90, 95% confidence interval (CI) = 0.86, 0.95] or high levels of deprivation (OR = 0.75, 95% CI = 0.70, 0.79) compared with low deprivation, those with lower incomes (for example, lowest quartile: OR = 0.70, 95% CI = 0.66, 0.73 compared with highest) and less education (for example, < 10 years: OR = 0.82, 95% CI = 0.78, 0.85 compared with 12+ years) and people born outside Sweden (OR = 0.74, 95% CI = 0.71, 0.78 compared with Swedish-born) were significantly less likely to pick up a prescription for AUD pharmacotherapy during the study period.
There appear to be socio-economic disparities in the receipt of pharmacotherapy for alcohol use disorder in Sweden.
药物治疗可能是酒精使用障碍(AUD)连续护理的重要组成部分。瑞典全民医疗保健系统强调为边缘化群体提供护理。在此背景下,主要目的是检验社区贫困和社会地位不利与接受AUD药物治疗之间的关联。
使用来自关联人口登记册的数据对一个开放队列进行了7年的随访。
瑞典。
2005年至2012年期间瑞典医院出院登记册中所有住院记录以及门诊护理登记册中所有诊所/办公室就诊记录所报告的与酒精相关的ICD - 10编码,用于识别62549例AUD病例。
主要结局是根据瑞典处方药登记册,患者在2005年至2012年期间领取的任何AUD药物治疗(纳曲酮、双硫仑、阿坎酸、纳美芬)(与未领取)。社区贫困使用总人口登记册的汇总数据定义;社会地位不利指标(收入、教育程度、原籍国)也来自该来源。
大约一半的病例(53.7%)领取了一种或多种AUD药物治疗处方。在调整模型中,与低贫困社区相比,生活在中度[优势比(OR)= 0.90,95%置信区间(CI)= 0.86,0.95]或高度贫困社区(OR = 0.75,95% CI = 0.70,0.79)的人、收入较低者(例如,最低四分位数:与最高四分位数相比,OR = 0.70,95% CI = 0.66,0.73)、受教育程度较低者(例如,< 10年:与12年及以上相比,OR = 0.82,95% CI = 0.78,0.85)以及在瑞典境外出生的人(与瑞典出生的人相比,OR = 0.74,95% CI = 0.71,0.78)在研究期间领取AUD药物治疗处方的可能性显著较低。
在瑞典,酒精使用障碍药物治疗的接受情况似乎存在社会经济差异。