钴催化的分子内氧化 C(sp)-H/N-H 羰基化反应在脂肪酰胺中的应用。
Cobalt-Catalyzed Intramolecular Oxidative C(sp)-H/N-H Carbonylation of Aliphatic Amides.
机构信息
College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan 430072, P. R. China.
National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
出版信息
Org Lett. 2017 Apr 21;19(8):2170-2173. doi: 10.1021/acs.orglett.7b00825. Epub 2017 Apr 13.
A cobalt-catalyzed reaction protocol is developed to achieve the intramolecular oxidative C(sp)-H/N-H carbonylation of aliphatic amides with CO. Various substituted propanamides are selectively transformed into corresponding succinimides in good to high yields. Notably, predominant selectivity for the carbonylation at the α-methyl groups of linear aliphatic amides is observed in this reaction system.
发展了一种钴催化反应体系，实现了 CO 参与的脂肪族酰胺的分子内氧化 C(sp)-H/N-H 羰基化反应。各种取代的丙酰胺可被选择性地转化为相应的琥珀酰亚胺，收率良好至较高。值得注意的是，在该反应体系中观察到线性脂肪族酰胺的α-甲基碳原子的羰基化反应具有主要的选择性。
Zotero 插件