钯催化N-烷基苯胺的芳族C-H键与CO和醇进行氧化羰基化反应以合成邻氨基苯甲酸酯。
Palladium-catalyzed oxidative carbonylation of aromatic C-H bonds of N-alkylanilines with CO and alcohols for the synthesis of o-aminobenzoates.
作者信息
Chen Ming, Ren Zhi-Hui, Wang Yao-Yu, Guan Zheng-Hui
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710127, P. R. China.
出版信息
J Org Chem. 2015 Jan 16;80(2):1258-63. doi: 10.1021/jo502581p. Epub 2015 Jan 5.
PMID:25560397
Abstract
A Pd(II)-catalyzed C-H monocarbonylation of N-alkylanilines for the synthesis of o-aminobenzoates has been developed. Various aliphatic alcohols and phenol were tolerated in the reaction to afford the corresponding o-aminobenzoates in good yields under mild balloon pressure of CO.
摘要
已开发出一种用于合成邻氨基苯甲酸酯的钯（II）催化的N-烷基苯胺C-H单羰基化反应。在该反应中，各种脂肪醇和苯酚均能耐受，在温和的CO气球压力下可高产率地得到相应的邻氨基苯甲酸酯。
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