链球菌中编码氯霉素抗性的染色体基因的异质性。
Heterogeneity of chromosomal genes encoding chloramphenicol resistance in streptococci.
作者信息
Pepper K, de Cespédès G, Horaud T
机构信息
Laboratoire des Staphylocoques et des Streptocoques, Institut Pasteur, Paris, France.
出版信息
Plasmid. 1988 Jan;19(1):71-4. doi: 10.1016/0147-619x(88)90065-0.
The DNA of 21 chloramphenicol-resistant plasmid-free streptococci was tested for sequence homology with the genes encoding chloramphenicol acetyltransferase (cat) of the staphylococcal plasmids pC194 and pC221. Homology to the cat gene of pC194 was detected in 11 strains, including the 8 strains of Streptococcus pneumoniae examined, and homology to cat of pC221 was found in 3 strains. The DNA of 7 strains did not detectably hybridize with either probe.
检测了21株无氯霉素抗性质粒的链球菌的DNA，以确定其与葡萄球菌质粒pC194和pC221中编码氯霉素乙酰转移酶（cat）的基因的序列同源性。在11株菌株中检测到与pC194的cat基因同源，包括所检测的8株肺炎链球菌，在3株菌株中发现与pC221的cat基因同源。7株菌株的DNA与任一探针均未检测到可察觉的杂交。
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