通过将葡萄球菌质粒pC194线性化并整合到肺炎链球菌染色体中获得氯霉素抗性。
Acquisition of chloramphenicol resistance by the linearization and integration of the entire staphylococcal plasmid pC194 into the chromosome of Streptococcus pneumoniae.
作者信息
Widdowson C A, Adrian P V, Klugman K P
机构信息
Medical Research Council, South African Institute for Medical Research, WITS Pneumococcal Diseases Research Unit, Johannesburg, South Africa.
出版信息
Antimicrob Agents Chemother. 2000 Feb;44(2):393-5. doi: 10.1128/AAC.44.2.393-395.2000.
Abstract
Chloramphenicol resistance in Streptococcus pneumoniae was associated with cat, which has 100% identity with cat(pC194) from Staphylococcus aureus. Inverse PCR with primers specific for pC194 confirmed that in some isolates the entire staphylococcal plasmid was present in the S. pneumoniae chromosome, with linearization having occurred between cat(pC194) and the origin of replication.
摘要
肺炎链球菌中的氯霉素抗性与cat相关，它与来自金黄色葡萄球菌的cat(pC194)具有100%的同一性。用针对pC194的特异性引物进行反向PCR证实，在一些分离株中，整个葡萄球菌质粒存在于肺炎链球菌染色体中，在cat(pC194)和复制起点之间发生了线性化。
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