Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Research Institute GUIDE, University of Groningen, Groningen, the Netherlands.
Retina. 2018 Apr;38(4):812-819. doi: 10.1097/IAE.0000000000001626.
To establish the predictive value of specific optical coherence tomography retinal features on visual outcomes and retinal thickness during anti-vascular endothelial growth factor treatment in patients with diabetic macular edema.
Post hoc analysis of compound data of a prospective, 6-month, multicenter, randomized controlled trial of 119 patients with diabetic macular edema receiving either intravitreal bevacizumab or ranibizumab were analyzed to assess the associations between baseline retinal morphologic parameters and change in best-corrected visual acuity and central subfield thickness. Based on the study protocol of the core study, best-corrected visual acuity and central subfield thickness were obtained before each mandatory monthly injection during 6 months.
The presence of serous retinal detachment at baseline was associated with significant improvement in best-corrected visual acuity letter score at Month 3 and Month 6 (P < 0.001 and P = 0.01, respectively). In addition, the presence of disorganization of retinal inner layers was associated with lower best-corrected visual acuity letter score at Month 3 and Month 6 (P < 0.05 and P = 0.01, respectively).
This study found that serous retinal detachment and disorganization of retinal inner layers were associated with different treatment responses to anti-vascular endothelial growth factor therapy in patients with diabetic macular edema.
确定特定的光学相干断层扫描视网膜特征在糖尿病性黄斑水肿患者接受抗血管内皮生长因子治疗期间对视力结果和视网膜厚度的预测价值。
对一项前瞻性、6 个月、多中心、随机对照试验的复合数据进行了事后分析，该试验共纳入 119 例糖尿病性黄斑水肿患者，分别接受玻璃体内贝伐单抗或雷珠单抗治疗，以评估基线视网膜形态参数与最佳矫正视力和中心凹下视网膜厚度变化之间的关系。根据核心研究的研究方案，在 6 个月期间每次强制性每月注射前均获得最佳矫正视力和中心凹下视网膜厚度。
基线时存在浆液性视网膜脱离与第 3 个月和第 6 个月最佳矫正视力字母评分的显著改善相关（P < 0.001 和 P = 0.01）。此外，视网膜内层紊乱与第 3 个月和第 6 个月的最佳矫正视力字母评分较低相关（P < 0.05 和 P = 0.01）。
本研究发现，浆液性视网膜脱离和视网膜内层紊乱与糖尿病性黄斑水肿患者接受抗血管内皮生长因子治疗的不同治疗反应相关。
