中国高致病性甲型禽流感（H5N6）病毒人间感染的初步流行病学评估
Preliminary Epidemiologic Assessment of Human Infections With Highly Pathogenic Avian Influenza A(H5N6) Virus, China.
作者信息
Jiang Hui, Wu Peng, Uyeki Timothy M, He Jianfeng, Deng Zhihong, Xu Wen, Lv Qiang, Zhang Jin, Wu Yang, Tsang Tim K, Kang Min, Zheng Jiandong, Wang Lili, Yang Bingyi, Qin Ying, Feng Luzhao, Fang Vicky J, Gao George F, Leung Gabriel M, Yu Hongjie, Cowling Benjamin J
机构信息
Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing.
WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
出版信息
Clin Infect Dis. 2017 Aug 1;65(3):383-388. doi: 10.1093/cid/cix334.
BACKGROUND
Since 2014, 17 human cases of infection with the newly emerged highly pathogenic avian influenza A(H5N6) virus have been identified in China to date. The epidemiologic characteristics of laboratory-confirmed A(H5N6) cases were compared to A(H5N1) and A(H7N9) cases in mainland China.
METHODS
Data on laboratory-confirmed H5N6, H5N1, and H7N9 cases identified in mainland China were analyzed to compare epidemiologic characteristics and clinical severity. Severity of confirmed H5N6, H5N1 and H7N9 cases was estimated based on the risk of severe outcomes in hospitalized cases.
RESULTS
H5N6 cases were older than H5N1 cases with a higher prevalence of underlying medical conditions but younger than H7N9 cases. Epidemiological time-to-event distributions were similar among cases infected with the 3 viruses. In comparison to a fatality risk of 70% (30/43) for hospitalized H5N1 cases and 41% (319/782) for hospitalized H7N9 cases, 12 (75%) out of the 16 hospitalized H5N6 cases were fatal, and 15 (94%) required mechanical ventilation.
CONCLUSION
Similar epidemiologic characteristics and high severity were observed in cases of H5N6 and H5N1 virus infection, whereas severity of H7N9 virus infections appeared lower. Continued surveillance of human infections with avian influenza A viruses remains an essential component of pandemic influenza preparedness.
背景
自2014年以来，中国迄今已确诊17例人感染新出现的高致病性甲型禽流感（H5N6）病毒病例。将实验室确诊的A（H5N6）病例的流行病学特征与中国大陆的A（H5N1）和A（H7N9）病例进行了比较。
方法
分析中国大陆确诊的H5N6、H5N1和H7N9病例的数据，以比较流行病学特征和临床严重程度。根据住院病例出现严重后果的风险评估确诊的H5N6、H5N1和H7N9病例的严重程度。
结果
H5N6病例比H5N1病例年龄更大，基础疾病患病率更高，但比H7N9病例年龄更小。三种病毒感染病例的流行病学事件发生时间分布相似。与住院H5N1病例70%（30/43）的死亡风险和住院H7N9病例41%（319/782）的死亡风险相比，16例住院H5N6病例中有12例（75%）死亡，15例（94%）需要机械通气。
结论
H5N6和H5N1病毒感染病例具有相似的流行病学特征和高严重程度，而H7N9病毒感染的严重程度似乎较低。持续监测人感染甲型禽流感病毒仍然是大流行性流感防范的重要组成部分。
Zotero 插件